Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Lipoprotein(a) is a risk factor for occurrence of acute myocardial infarction in patients with coronary vasospasm
Autore:
Miwa, K; Nakagawa, K; Yoshida, N; Taguchi, Y; Inoue, H;
Indirizzi:
Toyama Med & Pharmaceut Univ, Dept Internal Med 2, Toyama, Japan Toyama Med & Pharmaceut Univ Toyama Japan Internal Med 2, Toyama, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 5, volume: 35, anno: 2000,
pagine: 1200 - 1205
SICI:
0735-1097(200004)35:5<1200:LIARFF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
VARIANT ANGINA; DENSITY-LIPOPROTEIN; HEART-DISEASE; INTRACORONARY INJECTION; SERUM LIPOPROTEIN(A); CIRCADIAN VARIATION; FIBRINOPEPTIDE-A; ARTERY DISEASE; SPASM; ACETYLCHOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Miwa, K Kansai Elect Power Hosp, Dept Internal Med 2, Fukushima Ku, 2-1-7 Fukushima, Osaka 5530003, Japan Kansai Elect Power Hosp 2-1-7 Fukushima Osaka Japan 5530003 Japan
Citazione:
K. Miwa et al., "Lipoprotein(a) is a risk factor for occurrence of acute myocardial infarction in patients with coronary vasospasm", J AM COL C, 35(5), 2000, pp. 1200-1205

Abstract

OBJECTIVES The purpose of this study is to determine whether lipoprotein(a) (Lp[a]) is an independent risk factor for coronary spasm and occurrence of acute myocardial infarction (AMI) in patients with coronary spasm. BACKGROUND Although elevated serum Lp(a) levels are known to be associatedwith coronary atherosclerosis and AMI, the association between the elevated level of this lipoprotein and coronary spasm remains to be elucidated. METHODS Serum Lp(a) levels were measured using a latex immunoassay in 77 patients with coronary spasm but without a significant (>75%) fixed coronarystenosis, including 16 with prior myocardial infarction (MI), in 177 patients with a fixed. stenosis but without rest angina, including 114 with prior MI and in 81 control subjects without coronary artery disease. RESULTS The serum Lp(a) level in patients with coronary spasm (median; 17 mg/dl) was higher (p < 0.01) than in control subjects (12 mg/dl) but lower (p < 0.01) than in patients with a fixed stenosis (23 mg/dl). The incidenceof subjects with higher (>25 mg/dl) serum Lp(a) levels was higher in patients with a fixed stenosis (46%, p < 0.01) but not in patients with coronaryspasm (27%), compared with control subjects (21%). Among the patients withcoronary spasm, the incidence of higher Lp(a) levels was higher iii patients with than in those without a history of prior MI (56% vs, 21%, p < 0.05). The patients with higher Lp(a) levels had a higher incidence of prior MI than those without (41% vs. 13%, p < 0.05). The multivariate analysis confirmed that higher serum Lp(a) level is an independent determinant for prior MI in these patients (odds ratio, 4.19; 95%, confidence interval, 1.03 to 17.00). CONCLUSIONS Elevated serum level of Lp(a) was found to be associated with a history of prior hll in patients with coronary spasm, suggesting that Lp(a) may play an important role in the genesis of thrombotic coronary occlusion and the occurrence of AMI subsequent to coronary spasm. (J Am Coll Cardiol 2000;35:1200-5) (C) 2000 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:00:35