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Titolo:
Depth of cutaneous analgesia after application of a eutectic mixture of the local anesthetics lidocaine and prilocaine (EMLA cream)
Autore:
Wahlgren, CF; Quilding, H;
Indirizzi:
Karolinska Hosp & Inst, Dept Dermatol & Venerol, Stockholm, Sweden Karolinska Hosp & Inst Stockholm Sweden ol & Venerol, Stockholm, Sweden AstraZeneca, Clin Res & Dev, Sodertalje, Sweden AstraZeneca Sodertalje Sweden eneca, Clin Res & Dev, Sodertalje, Sweden
Titolo Testata:
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
fascicolo: 4, volume: 42, anno: 2000,
pagine: 584 - 588
SICI:
0190-9622(200004)42:4<584:DOCAAA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISUAL ANALOG SCALE; PAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Wahlgren, CF Karolinska Hosp, Dept Dermatol & Venerol, Box 120, SE-17176 Stockholm, Sweden Karolinska Hosp Box 120 Stockholm Sweden SE-17176 lm, Sweden
Citazione:
C.F. Wahlgren e H. Quilding, "Depth of cutaneous analgesia after application of a eutectic mixture of the local anesthetics lidocaine and prilocaine (EMLA cream)", J AM ACAD D, 42(4), 2000, pp. 584-588

Abstract

Background: EMLA cream, a eutectic mixture of lidocaine and prilocaine, isa topical anesthetic, frequently used to avoid pain during venipuncture and superficial surgery However, the depth of analgesia needs Further exploration. Objective: Our purpose was to investigate the depth of cutaneous analgesiaafter application of EMLA cream. Methods: In a single-blind crossover study, EMLA cream was applied under occlusion to the left thighs of 16 subjects. Eleven had application times of60 and 120 minutes. Five subjects had application times of 3 to 4 hours. Approximately 10 minutes after removal of the EMLA cream, a skin biopsy punch (diameter 4 mm) was inserted Co a depth of I mm into the skin and the subject rated the pain intensity on a visual analogue scale. If there was no pain or if pain was assessed as acceptable, a new biopsy punch was inserted at a new site to the depth of 2 mm. In this manner, the insertion depth wasgradually increased in steps of 1 mm down to a maximum of 6 mm. No skin specimens were removed. Results: After GO and 120 minutes of EMLA application the mean insertion depths with acceptable pain were 2.9 and 4.5 mm (P < .01), respectively. After 3 to 4 hours of application, 6-mm deep insertions were made with acceptable pain in all 5 subjects. Conclusion: Skin biopsy punch insertions in steps of I mm appear adequate for assessing the depth of cutaneous analgesia. Biopsy punch insertions with acceptable pain can be made to depths of 1 to 2 mm after 60 minutes, to 2to 3 mm after 120 minutes, and to 6 mm after 3 to 4 hours of EMLA cream application.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:34:47