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Titolo:
Histamine release induced by antimicrobial agents and effects of antimicrobial agents on vancomycin-induced histamine release from rat peritoneal mast cells
Autore:
Toyoguchi, T; Ebihara, M; Ojima, F; Hosoya, J; Shoji, T; Nakagawa, Y;
Indirizzi:
Yamagata Univ Hosp, Dept Pharm, Yamagata 9909585, Japan Yamagata Univ Hosp Yamagata Japan 9909585 Pharm, Yamagata 9909585, Japan
Titolo Testata:
JOURNAL OF PHARMACY AND PHARMACOLOGY
fascicolo: 3, volume: 52, anno: 2000,
pagine: 327 - 331
SICI:
0022-3573(200003)52:3<327:HRIBAA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RED-MAN SYNDROME; ANAPHYLACTOID REACTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Toyoguchi, T Yamagata Univ Hosp, Dept Pharm, 2-2-2 Iida Nishi, Yamagata 9909585, Japan Yamagata Univ Hosp 2-2-2 Iida Nishi Yamagata Japan 9909585 n
Citazione:
T. Toyoguchi et al., "Histamine release induced by antimicrobial agents and effects of antimicrobial agents on vancomycin-induced histamine release from rat peritoneal mast cells", J PHARM PHA, 52(3), 2000, pp. 327-331

Abstract

Vancomycin and certain fungicides may cause anaphylactoid reactions. We investigated the effects of vancomycin, miconazole and fluconazole on histamine release in rat peritoneal mast cells. Vancomycin and miconazole provokedhistamine release in a dose-dependent manner. In contrast, fluconazole didnot provoke histamine release at concentrations of 3 x 10(-6)-3 x 10(-3) M. Vancomycin is efficacious in the treatment of Gram-positive bacterial infections; patients presenting themselves with mixed infections require concomitant therapy with a second antimicrobial agent. We investigated the effectof fosfomycin sodium, cilastatin sodium or fluconazole on vancomycin-induced histamine release. Fosfomycin sodium inhibited vancomycin-induced histamine release but neither cilastatin sodium nor fluconazole inhibited it in the mole ratios of daily doses used in humans. These results suggest that vancomycin and miconazole provoke histamine release in rat mast cells, but that fluconazole probably does not, while fosfomycin sodium may inhibit vancomycin-induced histamine release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 02:55:20