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Titolo:
Haplotype dimorphism in a SNP collection from Drosophila melanogaster
Autore:
Teeter, K; Naeemuddin, M; Gasperini, R; Zimmerman, E; White, KP; Hoskins, R; Gibson, G;
Indirizzi:
N Carolina State Univ, Dept Genet, Raleigh, NC 27695 USA N Carolina State Univ Raleigh NC USA 27695 t Genet, Raleigh, NC 27695 USA Univ Michigan, Dept Biol, Ann Arbor, MI 48109 USA Univ Michigan Ann ArborMI USA 48109 , Dept Biol, Ann Arbor, MI 48109 USA Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley Drosophila Genome Project, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 Project, Berkeley, CA 94720 USA Stanford DNA Sequencing & Technol Ctr, Dept Biochem, Palo Alto, CA 94306 USA Stanford DNA Sequencing & Technol Ctr Palo Alto CA USA 94306 CA 94306 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL ZOOLOGY
fascicolo: 1, volume: 288, anno: 2000,
pagine: 63 - 75
SICI:
0022-104X(20000415)288:1<63:HDIASC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; DNA-SEQUENCES; POLYMORPHISMS; RECOMBINATION; ASSOCIATIONS; POPULATIONS; DIVERGENCE; ARRAYS; TOOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Gibson, G N Carolina State Univ, Dept Genet, Gardiner Hall, Raleigh, NC 27695 USA N Carolina State Univ Gardiner Hall Raleigh NC USA 27695 695 USA
Citazione:
K. Teeter et al., "Haplotype dimorphism in a SNP collection from Drosophila melanogaster", J EXP ZOOL, 288(1), 2000, pp. 63-75

Abstract

A moderate resolution single nucleotide polymorphism (SNP) map of the genome of Drosophila melanogaster that is designed for use in quantitative genetic mapping is described. Seventeen approximately 500 nucleotide gene sequences spaced at 10 to 20 centimorgan intervals were combined with 49 shortersequence tag sites (STSs) at 5 to 10 centimorgan intervals to generate a map that should not leave any gaps greater than one half of a chromosome armwhen any two wild type lines are compared. Of 20 markers with sufficient polymorphism to construct haplotype cladograms, 13 showed evidence for two divergent classes of haplotype. The possible mechanisms for and implicationsof the unexpected finding that two thirds of all short gene sequences in D. melanogaster may be dimorphic are discussed, including the suggestion that admixture between two separate lineages may have been a major event in the history of the species. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 21/09/20 alle ore 14:43:01