Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of immune modulation in primary HIV infection
Autore:
Lori, F; Lisziewicz, J;
Indirizzi:
IRCCS, RIGHT, Policlin San Matteo, Washington, DC 20007 USA IRCCS Washington DC USA 20007 liclin San Matteo, Washington, DC 20007 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
fascicolo: 1, volume: 14, anno: 2000,
pagine: 45 - 48
SICI:
0393-974X(200001/03)14:1<45:ROIMIP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; T-CELLS; HYDROXYUREA; REPLICATION; MACROPHAGE; DIDANOSINE; LYMPHOCYTES; COMBINATION; SUPPRESSION;
Keywords:
HIV; immune-modulation; hydroxyurea; early treatment; primary HIV infection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Lori, F IRCCS, RIGHT, Policlin San Matteo, Med Dent Bldg,SW307,3900 Reservoir Rd NW, Washington, DC 20007 USA IRCCS Med Dent Bldg,SW307,3900 Reservoir Rd NW Washington DC USA 20007
Citazione:
F. Lori e J. Lisziewicz, "Role of immune modulation in primary HIV infection", J BIOL REG, 14(1), 2000, pp. 45-48

Abstract

Hydroxyurea inhibits HIV without attacking the virus directly. By inhibiting a cellular enzyme (ribonucleotide reductase) the drug decreases the intracellular concentration of deoxynucleotide triphosphates, thus favoring theincorporation of other drugs, such as the reverse transcriptase inhibitors, into the nascent viral DNA. A large body of data has shown that hydroxyurea can be successfully used during chronic infection. In this manuscript wereview the use of hydroxyurea during primary HIV infection. In several independent studies hydroxyurea has been shown to: 1) inhibit HIV in combination with a reverse transcriptase inhibitor and a protease inhibitor as efficiently as with standard highly active antiretroviral therapies; 2) stimulate the immune system by increasing the percentage of naive cells and the percentage of cells capable of responding to antigens; 3) "cool down" the immune system hyper-activation. The role of hydroxyurea in inducing control of HIV during structured treatment interruptions remains to be clarified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:05:32