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Titolo:
Genomic organization of the serine protease light chain of mouse complement factor I gene
Autore:
Jiang, N; Molina, H;
Indirizzi:
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 d, Dept Med, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 l & Immunol, St Louis, MO 63110 USA Vet Adm Med Ctr, St Louis, MO 63106 USA Vet Adm Med Ctr St Louis MO USA 63106 Adm Med Ctr, St Louis, MO 63106 USA
Titolo Testata:
IUBMB LIFE
fascicolo: 2, volume: 49, anno: 2000,
pagine: 109 - 112
SICI:
1521-6543(200002)49:2<109:GOOTSP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INACTIVATOR; EVOLUTION;
Keywords:
complement factor I; genomic organization; light chain; serine protease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Molina, H Washington Univ, Sch Med, Dept Med, Rheumatol Box 8045,660 S Euclid Ave, St Louis, MO 63110 USA Washington Univ Rheumatol Box 8045,660 S Euclid Ave St Louis MO USA 63110
Citazione:
N. Jiang e H. Molina, "Genomic organization of the serine protease light chain of mouse complement factor I gene", IUBMB LIFE, 49(2), 2000, pp. 109-112

Abstract

A portion of the mouse complement factor I (mCFI) gene encoding for the mCFI light chain was cloned from a mouse 129/SVJ1 bacterial artificial chromosome library. It contains five exons and four introns, The intron sizes areremarkably different from the human homolog, Several polymorphisms were found in exon 13, One polymorphism was in the coding region, which causes a threonine in the Balb/c mCFI to be replaced by an isoleucine in the 129/SVJ1mCFI, The other two polymorphisms are located in the 3' untranslated region. The organization of the serine protease domain in mCFI is similar to that of trypsin but very different from that of the other complement serine proteases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:30:27