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Titolo:
Reduced expression of the cell-cycle inhibitor p27(Kip1) is associated with progression and lymph node metastasis of gastric carcinoma
Autore:
Kim, DH; Lee, HI; Nam, ES; Shin, HS; Sohn, JH; Park, CH; Yoon, DS; Song, SY; Park, YE;
Indirizzi:
Hallym Univ, Coll Med, Dept Pathol, Seoul, South Korea Hallym Univ SeoulSouth Korea Coll Med, Dept Pathol, Seoul, South Korea Hallym Univ, Coll Med, Dept Gen Surg, Seoul, South Korea Hallym Univ Seoul South Korea ll Med, Dept Gen Surg, Seoul, South Korea SungKyunKwan Univ, Sch Med, Samsung Med Ctr, Dept Diagnost Pathol, Seoul, South Korea SungKyunKwan Univ Seoul South Korea Diagnost Pathol, Seoul, South Korea
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 3, volume: 36, anno: 2000,
pagine: 245 - 251
SICI:
0309-0167(200003)36:3<245:REOTCI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT KINASE INHIBITOR; P27/KIP1 EXPRESSION; INVERSE CORRELATION; CDK INHIBITOR; BREAST-CANCER; MICE LACKING; P27; PROTEIN; GROWTH; TUMORS;
Keywords:
gastric carcinoma; immunohistochemistry; lymph node metastasis; p27kip1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, DH Hallym Univ, Coll Med, Kang Dong Sacred Heart Hosp, Dept Pathol, 445 Gil Dong, Seoul 134701, South Korea Hallym Univ 445 Gil Dong Seoul South Korea 134701 01, South Korea
Citazione:
D.H. Kim et al., "Reduced expression of the cell-cycle inhibitor p27(Kip1) is associated with progression and lymph node metastasis of gastric carcinoma", HISTOPATHOL, 36(3), 2000, pp. 245-251

Abstract

Aims: p27(Kip1) (p27), a cyclin-dependent kinase inhibitor, plays an important role as inhibiting the progression of the cell cycle. Decreased expression of p27 is associated with high histological grade and aggressiveness of several human tumours. We aimed to evaluate the role of p27 in the progression and metastasis of gastric carcinoma. Methods and results: We analysed the expression of p27 in 67 primary gastric carcinomas and 31 lymph node metastases by immunohistochemistry. Reducedexpression of p27 was found more frequently in advanced gastric cancer (40.9%) than in early gastric cancer (15.6%) (P < 0.001). Decreased p27 expression correlated with large tumour size, high histological grade, lymphatic invasion, advanced stage, deep invasion, lymph node metastasis and recurrence. The expression of p27 showed an inverse correlation with the Ki67 labelling index. There was a significant reduction of p27 expression in metastatic tumour cells in lymph nodes (mean positive cells: 3.7%) when compared tothe corresponding primary gastric carcinomas (mean positive cells: 8.1%) (P = 0.008). Conclusions: Alterations of p27 expression may play an important role in the progression and metastasis to lymph node of tumour cells in human gastric carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:33:49