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Titolo:
Variation in the histological pattern of nodal involvement by gamma/delta T-cell lymphoma
Autore:
Charton-Bain, MC; Brousset, P; Bouabdallah, R; Gaulard, P; Merlio, JP; Dubus, P; Rostaing, L; de Roux, C; Weiller, PJ; Hassoun, J; Xerri, L;
Indirizzi:
Inst J Paoli I Calmettes, Serv Anat Pathol, F-13273 Marseille, France InstJ Paoli I Calmettes Marseille France F-13273 3273 Marseille, France Inst J Paoli I Calmettes, Serv Hematol Clin, F-13273 Marseille, France Inst J Paoli I Calmettes Marseille France F-13273 3273 Marseille, France Hop Purpan, Toulouse, France Hop Purpan Toulouse FranceHop Purpan, Toulouse, France Hop Henri Mondor, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 Mondor, F-94010 Creteil, France CHU Bordeaux Pessac, Bordeaux, France CHU Bordeaux Pessac Bordeaux France U Bordeaux Pessac, Bordeaux, France Hop Rangueuil, Toulouse, France Hop Rangueuil Toulouse FranceHop Rangueuil, Toulouse, France Hop Enfants La Timone, Marseille, France Hop Enfants La Timone MarseilleFrance nts La Timone, Marseille, France
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 3, volume: 36, anno: 2000,
pagine: 233 - 239
SICI:
0309-0167(200003)36:3<233:VITHPO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; RECEPTOR-GAMMA-DELTA; LYMPHOPROLIFERATIVE DISORDER; ALPHA-BETA; LOCALIZATION; LYMPHOCYTES; EXPRESSION; PATIENT; SUBSET;
Keywords:
gamma/delta T-cell receptor; lymph-node; peripheral gamma delta T-cell lymphoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Xerri, L Inst J Paoli I Calmettes, Serv Anat Pathol, 232 Bd St Marguerite,BP 156, F-13273 Marseille, France Inst J Paoli I Calmettes 232 Bd St Marguerite,BP 156 Marseille France F-13273
Citazione:
M.C. Charton-Bain et al., "Variation in the histological pattern of nodal involvement by gamma/delta T-cell lymphoma", HISTOPATHOL, 36(3), 2000, pp. 233-239

Abstract

Aims: Gamma-delta (gamma delta) T-cell non-Hodgkin's lymphomas (NHLs) usually present with liver, spleen and marrow infiltration. Lymph node involvement by gamma delta T-cell NHL has been rarely documented so far; its histological pattern needs to be further defined. Methods and results: Two cases of nodal gamma delta T-cell NHL are reported: case 1, a 44-year-old man, presented with cytomegalovirus retinitis and superficial lymphadenopathies. Histological analysis of an inguinal lymph node showed complete destruction by a diffuse pleomorphic lymphoid proliferation, which was positive for CD2, CD3, CD43, CD45, TIA-1 and granzyme B, and displayed a gamma delta phenotype (delta TCR1+, V delta 1+, V delta 2-, Vdelta 3-, beta F1-). Bone marrow was normal. Case 2, a male 24-year-old patient with a history of renal transplantation, presented with hepatosplenomegaly and supraclavicular lymph node enlargement. Lymph node architecture was globally preserved. Peripheral sinuses contained scattered nests of medium-sized irregular lymphoid cells. Bone-marrow was infiltrated. Phenotype showed positivity for CD2, CD3, CD45 and TIA1 and expression of gamma delta TCR (delta TCR1+, delta V1+, delta V2-, delta V3-, beta F1-). Both patientsdied a short time after diagnosis. Conclusions: These observations suggest that at least two forms of nodal gamma delta T-cell NHL may be encountered: one mimicking classical alpha beta T-cell NHL, with diffuse pleomorphic cell proliferation, and one displaying sinusoidal neoplastic infiltration suggesting a close relationship with hepatosplenic gamma delta T-cell NHL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 23:45:17