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Titolo:
HBME-1, MOC-31, WT1 and calretinin: an assessment of recently described markers for mesothelioma and adenocarcinoma
Autore:
Oates, J; Edwards, C;
Indirizzi:
Birmingham Heartlands Hosp, Dept Histopathol, Birmingham B9 5ST, W Midlands, England Birmingham Heartlands Hosp Birmingham W Midlands England B9 5ST, England
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 4, volume: 36, anno: 2000,
pagine: 341 - 347
SICI:
0309-0167(200004)36:4<341:HMWACA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-MALIGNANT MESOTHELIOMA; LEU M1 ANTIGEN; MONOCLONAL-ANTIBODY; PULMONARY ADENOCARCINOMA; EPITHELIAL MESOTHELIOMA; DIFFERENTIAL EXPRESSION; PLEURAL MESOTHELIOMAS; LUNG ADENOCARCINOMAS; N-CADHERIN; DIAGNOSIS;
Keywords:
adenocarcinoma; diagnosis; immunohistochemistry; mesothelioma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Oates, J Birmingham Heartlands Hosp, Dept Histopathol, Birmingham B9 5ST, W Midlands, England Birmingham Heartlands Hosp Birmingham W Midlands England B9 5ST
Citazione:
J. Oates e C. Edwards, "HBME-1, MOC-31, WT1 and calretinin: an assessment of recently described markers for mesothelioma and adenocarcinoma", HISTOPATHOL, 36(4), 2000, pp. 341-347

Abstract

Aims: To evaluate HBME-1, WT1, calretinin and MOC-31 in the differential diagnosis of pleural mesothelioma and adenocarcinoma of the lung. Methods and results: Paraffin-embedded formalin-fixed blocks from six reactive pleuras, 42 mesotheliomas and 40 adenocarcinomas were used. Sections were stained for Leu-M1, HBME-1, calretinin, WT1 and MOC-31. Leu-M1 was positive or equivocal in 34% of mesotheliomas and in 78% of adenocarcinomas; reactive pleuras were all negative. HBME-1 was positive or equivocal in 76% of mesotheliomas and in 73% of adenocarcinomas; five reactive pleuras were positive. Calretinin was positive or equivocal in 92% of mesotheliomas and in 73% of adenocarcinomas; two reactive pleura were equivocal and four were positive. WT1 was positive or equivocal in 72% of mesotheliomas (excluding autopsy cases) and in 20% of adenocarcinomas; all reactive pleuras were positive. MOC-31 was positive or equivocal in 5% of mesotheliomas and in 90% of adenocarcinomas; all reactive pleuras were negative. The reaction with Leu-M1 was graded as equivocal in 25% of the adenocarcinomas. All 24 of the autopsy cases of mesothelioma were negative for WT1 and in many operative specimens only the periphery was stained. Conclusions: Neither calretinin nor HBME-1 are sufficiently discriminatoryto be of use, even as members of a panel of antibodies. WT1 shows some promise, but it cannot be used on autopsy material. The utility of MOC-31 is confirmed, and outperforms Leu-M1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:03:37