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Titolo:
Tissue plasminogen activator controls multiple forms of synaptic plasticity and memory
Autore:
Calabresi, P; Napolitano, M; Centonze, D; Marfia, GA; Gubellini, P; Teule, MA; Berretta, N; Bernardi, G; Frati, L; Tolu, M; Gulino, A;
Indirizzi:
Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 eurol Clin, I-00133 Rome, Italy Osped Santa Lucia, IRCCS, Rome, Italy Osped Santa Lucia Rome ItalyOsped Santa Lucia, IRCCS, Rome, Italy Univ La Sapienza, Dipartimento Med Sperimentale & Patol, Rome, Italy Univ La Sapienza Rome Italy mento Med Sperimentale & Patol, Rome, Italy CNR, Ist Med Sperimentale, I-00137 Rome, Italy CNR Rome Italy I-00137CNR, Ist Med Sperimentale, I-00137 Rome, Italy CNR, Ist Psicobiol, Rome, Italy CNR Rome ItalyCNR, Ist Psicobiol, Rome, Italy Neuromed Inst, Pozzilli, Italy Neuromed Inst Pozzilli ItalyNeuromed Inst, Pozzilli, Italy
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 12, anno: 2000,
pagine: 1002 - 1012
SICI:
0953-816X(200003)12:3<1002:TPACMF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RAT STRIATAL NEURONS; DEVELOPING CEREBELLUM; NEURAL DEVELOPMENT; GRANULE NEURONS; CONTEXTUAL FEAR; SPATIAL NOVELTY; MESSENGER-RNA; MICE LACKING; LATE-PHASE;
Keywords:
learning; long-term depression; long-term potentiation; synaptic plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Calabresi, P Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, Via Tor Vergata135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata135 Rome Italy I-00133
Citazione:
P. Calabresi et al., "Tissue plasminogen activator controls multiple forms of synaptic plasticity and memory", EUR J NEURO, 12(3), 2000, pp. 1002-1012

Abstract

Induction of long-term depression (LTD) in rat striatal slices revealed that this form of synaptic plasticity is coupled to an increased expression of tissue-plasminogen activator (t-PA) mRNA, as detected by the mRNA differential display technique. To further investigate the involvement of this gene in synaptic remodelling following striatal LTD, we recorded electrical activity from mice lacking the gene encoding t-PA (t-PA-KO) and from wild-type (WT) mice. Tetanic stimulation induced LTD in the large majority of striatal neurons recorded from WT mice. Conversely, LTD was absent in a significant proportion of striatal neurons obtained from mice lacking t-PA. Electrophysiological recordings obtained from hippocampal slices in the CA1 area showed that mainly the late phase of long-term potentiation (LTP) was reduced in t-PA-KO mice. Learning and memory-related behavioural abnormalities were also found in these transgenic mice. Disruption of the t-PA gene, in fact, altered both the context conditioning test, a hippocampus-related behavioural task, and the two-way active avoidance, a striatum-dependent task. Inan open field object exploration task, t-PA-KO mice expressed deficits in habituation and reactivity to spatial change that are consistent with an altered hippocampal function. Nevertheless, decreased rearing and poor initial object exploration were also observed, further suggesting an altered striatal function. These data indicate that t-PA plays a critical role in the formation of various forms of synaptic plasticity and memory.

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Documento generato il 25/10/20 alle ore 15:46:05