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Titolo:
Metabolic coupling between glia and neurons is necessary for maintaining respiratory activity in transverse medullary slices of neonatal mouse
Autore:
Hulsmann, S; Oku, Y; Zhang, WQ; Richter, DW;
Indirizzi:
Univ Gottingen, Zentrum Physiol & Pathophysiol, Abt Neuro & Sinnesphysiol,D-37073 Gottingen, Germany Univ Gottingen Gottingen Germany D-37073 siol,D-37073 Gottingen, Germany Kyoto Univ, Inst Frontier Med Sci, Dept Med Syst Control, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ Kyoto Japan 6068397 t Control, Sakyo Ku, Kyoto 6068397, Japan
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 12, anno: 2000,
pagine: 856 - 862
SICI:
0953-816X(200003)12:3<856:MCBGAN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMINE-SYNTHETASE; EXTRACELLULAR POTASSIUM; SYNAPTIC TRANSMISSION; CELL METABOLISM; RAT-BRAIN; FLUOROCITRATE; FLUOROACETATE; INVIVO; LOCALIZATION; HIPPOCAMPUS;
Keywords:
brainstem; fluoroacetate; glutamine transfer; methionine sulfoximine; neuronal network;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Hulsmann, S Univ Gottingen, Zentrum Physiol & Pathophysiol, Abt Neuro & Sinnesphysiol,Humboldtallee 23, D-37073 Gottingen, Germany Univ Gottingen Humboldtallee 23 Gottingen Germany D-37073 any
Citazione:
S. Hulsmann et al., "Metabolic coupling between glia and neurons is necessary for maintaining respiratory activity in transverse medullary slices of neonatal mouse", EUR J NEURO, 12(3), 2000, pp. 856-862

Abstract

The respiratory rhythm is generated and regulated by a neuronal network within the lower brainstem. While the neuronal mechanisms of rhythm generation have been extensively investigated, the contribution of glial cells remains to be determined. Here we report the effect of specific blockade of the glial Krebs cycle and glutamine synthetase on the neuronal activity of the respiratory network. Application of 5 mm fluoroacetate, which selectively blocks the glial Krebs cycle, suppressed rhythmic respiratory burst activity. Substitution of either the Krebs cycle substrate isocitrate (3 mm) or glutamine (3 mm) restored rhythmic network activity. Blockade of glutamine synthetase by methionine sulfoximine (0.5 mm) suppressed rhythmic burst activity as well. Resubstitution of glutamine (3 mm) was able to restore rhythmicactivity in the presence of methionine sulfoximine. This data demonstratesthat the glutamate-glutamine cycle in astrocytes and their supply of glutamine to neuronal glutamatergic terminals is essential for the rhythm generation in the respiratory centre.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:44:40