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Titolo:
Physiological role of group III metabotropic glutamate receptors in visually responsive neurons of the rat superficial superior colliculus
Autore:
Cirone, J; Salt, TE;
Indirizzi:
Univ Coll London, Dept Visual Sci, Inst Ophthalmol, London EC1V 9EL, England Univ Coll London London England EC1V 9EL almol, London EC1V 9EL, England
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 12, anno: 2000,
pagine: 847 - 855
SICI:
0953-816X(200003)12:3<847:PROGIM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; LATERAL PERFORANT PATH; SYNAPTIC TRANSMISSION; MESSENGER-RNA; NEUROTRANSMITTER RELEASE; MONOCLONAL-ANTIBODY; SIGNAL-TRANSDUCTION; GANGLION-CELLS; IN-VIVO; LOCALIZATION;
Keywords:
in vivo; iontophoresis; L-AP4; mGluR; MPPG; vision;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Cirone, J Univ Coll London, Dept Visual Sci, Inst Ophthalmol, 11-43 Bath St, London EC1V 9EL, England Univ Coll London 11-43 Bath St London England EC1V 9EL England
Citazione:
J. Cirone e T.E. Salt, "Physiological role of group III metabotropic glutamate receptors in visually responsive neurons of the rat superficial superior colliculus", EUR J NEURO, 12(3), 2000, pp. 847-855

Abstract

There is evidence from immunohistochemical and in situ hybridization studies for the presence of Group I, II and III metabotropic glutamate receptors(mGluRs) in the rat superficial superior colliculus (SSC). The purpose of this study was to investigate if manipulation of Group III mGluRs affects visual responses in the SSC. Drugs were applied by iontophoresis and single neuron activity was recorded extracellularly. L-AP4 (Group III agonist) resulted in a reduction of visual responses in most neurons, but also a potentiation in others. The effect of L-AP4 is drug- and stereospecific in that application of D-AP4 did not significantly affect visual responses. L-AP4 application also resulted in a potentiation of the response to iontophoretically applied NMDA. The effects of MPPG and CPPG (Group III antagonists) werecompared with the effect of L-AP4 in the same neuron and were found to produce the opposite effect to L-AP4. Furthermore, the effect of L-AP4 could be blocked by coapplication of MPPG or CPPG. Presynaptic depression of glutamate release is a possible mechanism by which L-AP4 could reduce visual responses in the SSC whereas the potentiation of visual responses by L-AP4 could be due to a reduction of GABAergic inhibition. The finding that MPPG andCPPG, as well as antagonizing the L-AP4 effect, have a direct effect on visual responses suggests that Group III mGluRs are activated by endogenous transmitter released during visual stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 13:21:02