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Titolo:
Correlations between insulin sensitivity and bone mineral density in non-diabetic men
Autore:
Abrahamsen, B; Rohold, A; Henriksen, JE; Beck-Nielsen, H;
Indirizzi:
Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense C, Denmark Odense Univ Hosp Odense Denmark C Endocrinol, DK-5000 Odense C, Denmark
Titolo Testata:
DIABETIC MEDICINE
fascicolo: 2, volume: 17, anno: 2000,
pagine: 124 - 129
SICI:
0742-3071(200002)17:2<124:CBISAB>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALKALINE-PHOSPHATASE ACTIVITY; DUAL-PHOTON-ABSORPTIOMETRY; FACTOR BINDING PROTEIN-1; X-RAY ABSORPTIOMETRY; POSTMENOPAUSAL WOMEN; BODY-COMPOSITION; OLDER WOMEN; TISSUE MASS; MELLITUS; TYPE-1;
Keywords:
body composition; bone mineral density; cardiovascular disease; glucose metabolism; insulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Abrahamsen, B Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense C, DenmarkOdense Univ Hosp Odense Denmark C K-5000 Odense C, Denmark
Citazione:
B. Abrahamsen et al., "Correlations between insulin sensitivity and bone mineral density in non-diabetic men", DIABET MED, 17(2), 2000, pp. 124-129

Abstract

Aims To investigate relationships between bone mineral density (BMD), insulin secretion and insulin sensitivity, controlling for body composition, inview of data suggesting that hypoglycaemia leads to decreased osteoblast proliferation and a negative calcium balance and that insulin stimulates osteoblast differentiation and collagen synthesis, with no clear evidence if this response in impaired in insulin resistance. Methods Femur and whole body (WB) BMD was measured in 55 male patients with ischaemic heart disease and 40 healthy men, using a Hologic QDR-2000 densitometer, Insulin sensitivity (S-i) was estimated as the rate of glucose disappearance divided by the area under the insulin curve during an intravenous glucose tolerance test. Results Insulin and C-peptide levels were not correlated with BMD, but S-iwas a significant: predictor of femur (log, r = 0.35) and WB BMD (log r = 0.29, both P < 0.01), even after controlling for weight: and age. Fat mass (FM) was a predictor of BMD (femur: r = 0.33 P < 0.01, WB: r = 0.43 P < 0.001). In the femur the association with FM disappeared when log(S-i) was entered in the regression. Lean body mass (LBM) contributed significantly to BMD (r = 0.50 and r = 0.66, both P < 0.001). Conclusions These results are compatible with a direct influence of lean body mass on bone, while the impact of fat mass may consist of insulin resistance with increased insulin exposure of bone. It is hypothesized that patients with insulin resistance in the metabolic pathway do not exhibit resistance to the skeletal actions of insulin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 14:50:28