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Titolo:
Corticosteroids and interferons inhibit cytokine-induced production of IL-8 by human endothelial cells
Autore:
Nyhlen, K; Linden, M; Andersson, R; Uppugunduri, S;
Indirizzi:
Fac Hlth Sci, Dept Med & Care, Div Pharmacol, S-58185 Linkoping, Sweden Fac Hlth Sci Linkoping Sweden S-58185 armacol, S-58185 Linkoping, Sweden Astro Draco AB, Dept Cell & Mol Biol, S-22100 Lund, Sweden Astro Draco ABLund Sweden S-22100 Cell & Mol Biol, S-22100 Lund, Sweden Linkoping Univ Hosp, Hosp Pharm, S-58185 Linkoping, Sweden Linkoping Univ Hosp Linkoping Sweden S-58185 , S-58185 Linkoping, Sweden
Titolo Testata:
CYTOKINE
fascicolo: 4, volume: 12, anno: 2000,
pagine: 355 - 360
SICI:
1043-4666(200004)12:4<355:CAIICP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-8 GENE-EXPRESSION; TRANSCRIPTIONAL INHIBITION; E-SELECTIN; GAMMA; CHEMOKINE; ALPHA; MODULATION; INDUCTION; RECEPTORS;
Keywords:
HUVEC; cytokines; IL-8; steroids; interferons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Nyhlen, K Fac Hlth Sci, Dept Med & Care, Div Pharmacol, S-58185 Linkoping,Sweden Fac Hlth Sci Linkoping Sweden S-58185 -58185 Linkoping, Sweden
Citazione:
K. Nyhlen et al., "Corticosteroids and interferons inhibit cytokine-induced production of IL-8 by human endothelial cells", CYTOKINE, 12(4), 2000, pp. 355-360

Abstract

IL-8, secreted by endothelial cells at the site of inflammation, participates in recruitment and transmigration of leukocytes, IL-8 may also have pathophysiological consequences in inflammatory and immunological disorders. We have investigated the effect of interferons (IFNs) and glucocorticosteroids (GCs) on cytokine induced secretion and production of IL-8 by human umbilical endothelial cells (HUVEC), There was a low spontaneous secretion of IL-8 by unstimulated HUVEC which increased after 6 or 24 h of stimulation with the pro-inflammatory cytokines TNF-alpha or IL-1 beta, IFN-gamma as wellas the GCs, Dexamethasone and Budesonide, inhibited TNF-alpha induced IL-8secretion in a dose-dependent manner. IFNs may have a general modulating effect, since IFN-alpha also inhibited the TNF-alpha-induced IL-8 secretion. There was a slight, but significant, increase in the content of intracellular IL-8 in stimulated HUVEC, However, there was no difference between stimulation with IL-1 beta or TNF-alpha alone or in combination with IFNs or GCs, whereas inhibition of IL-8 secretion with monensin increased IL-8 content suggesting that IFNs and GCs inhibit synthesis rather than secretion of IL-8, In conclusion, IFNs or GCs may be useful for inhibiting IL-8 production by endothelial cells and could thus be used for therapeutic modulation ofthe inflammatory response. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:56:42