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Titolo:
Abnormalities of cardiac sympathetic innervation in arrhythmogenic right ventricular cardiomyopathy - Quantitative assessment of presynaptic norepinephrine reuptake and postsynaptic beta-adrenergic receptor density with positron emission tomography
Autore:
Wichter, T; Schafers, M; Rhodes, CG; Borggrefe, M; Lerch, H; Lammertsma, AA; Hermansen, F; Schober, O; Breithardt, G; Camici, PG;
Indirizzi:
Univ Hosp Munster, Dept Cariol & Angiol, Munster, Germany Univ Hosp Munster Munster Germany ept Cariol & Angiol, Munster, Germany Inst Arteriosclerosis Res, Munster, Germany Inst Arteriosclerosis Res Munster Germany lerosis Res, Munster, Germany Dept Nucl Med, Munster, Germany Dept Nucl Med Munster GermanyDept Nucl Med, Munster, Germany Hammersmith Hosp, MRC, Cyclotron Unit, London W12 0HS, England HammersmithHosp London England W12 0HS on Unit, London W12 0HS, England Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, London, England Univ London Imperial Coll Sci Technol & Med London England don, England
Titolo Testata:
CIRCULATION
fascicolo: 13, volume: 101, anno: 2000,
pagine: 1552 - 1558
SICI:
0009-7322(20000404)101:13<1552:AOCSII>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYSPLASIA; TACHYCARDIA; PET; RADIOLIGAND; APOPTOSIS; BLOOD; HEART;
Keywords:
cardiomyopathy; ventricular tachycardia; nervous system, autonomic; receptors, adrenergic, beta; tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Wichter, T Univ Munster, Med Klin & Poliklin, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 D-48129 Munster, Germany
Citazione:
T. Wichter et al., "Abnormalities of cardiac sympathetic innervation in arrhythmogenic right ventricular cardiomyopathy - Quantitative assessment of presynaptic norepinephrine reuptake and postsynaptic beta-adrenergic receptor density with positron emission tomography", CIRCULATION, 101(13), 2000, pp. 1552-1558

Abstract

Background-The frequent provocation of ventricular tachycardia by stress or catecholamines and the efficacy of antiarrhythmic drugs with antiadrenergic properties suggest an involvement of the cardiac adrenergic system in arrhythmogenesis in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Previous studies demonstrated abnormalities of the presynapticuptake-1 assessed by I-123-MIBG-single-photon emission computed tomography. Methods and Results-This study investigated neuronal reuptake of norepinephrine (uptake-1) and beta-adrenergic receptor density in 8 patients with ARVC and 39 age-matched control subjects. All subjects underwent positron emission tomography with the volume of distribution (V-d) of [C-11]hydroxyephedrine (C-11-HED) used to assess presynaptic norepinephrine reuptake, the maximum binding capacity (B-max) of [C-11]CGP-12177 (C-11-CGP-12177) to assess postsynaptic beta-adrenergic receptor density, and [O-15]H2O for quantification of myocardial blood now. Patients with ARVC demonstrated a highly significant global reduction in postsynaptic beta-adrenergic receptor densitycompared with that in control subjects (B-max of C-11-CGP-12177: 5.9+/-1.3vs 10.2+/-2.9 pmol/g tissue, P<0.0007), whereas the presynaptic uptake-1 tended toward reduction only (V-d of C-11-HED: 59.1+/-25.2 vs 71.0+/-18.8 mL/g tissue, NS). There were no differences in myocardial blood now between the groups, and plasma norepinephrine was within normal limits in patients and control subjects. Conclusions-The findings demonstrate a significant reduction of myocardialbeta-adrenergic receptor density in patients with ARVC. This may result from a secondary downregulation after increased local synaptic norepinephrinelevels caused by increased firing rates of the efferent neurons or as the result of impaired presynaptic catecholamine reuptake. These findings give new insights into the pathophysiology of arrhythmogenesis in ARVC, with potential impact on diagnostic evaluation and therapeutic management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:05:19