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Titolo:
Metallothionein in human disease
Autore:
Simpkins, CO;
Indirizzi:
Nassau Cty Med Ctr, E Meadow, NY 11554 USA Nassau Cty Med Ctr E Meadow NYUSA 11554 Med Ctr, E Meadow, NY 11554 USA Hamot Res Ctr, Erie, PA USA Hamot Res Ctr Erie PA USAHamot Res Ctr, Erie, PA USA Tri State Emergency Syst, Erie, PA USA Tri State Emergency Syst Erie PA USA State Emergency Syst, Erie, PA USA
Titolo Testata:
CELLULAR AND MOLECULAR BIOLOGY
fascicolo: 2, volume: 46, anno: 2000,
pagine: 465 - 488
SICI:
0145-5680(200003)46:2<465:MIHD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL OXYGEN-CONSUMPTION; AMYOTROPHIC-LATERAL-SCLEROSIS; ANTISENSE DOWN-REGULATION; GROWTH INHIBITORY FACTOR; NITRIC-OXIDE; ALZHEIMERS-DISEASE; EXTRACELLULAR METALLOTHIONEIN; SUPEROXIDE-DISMUTASE; TRAUMA-HEMORRHAGE; CADMIUM-METALLOTHIONEIN;
Keywords:
metallothionein; apometallothionein; immune system; shock; diabetes; coronary artery disease; multiple organ failure; amyotrophic lateral sclerosis; pollution; cancer; arthritis; apoptosis; MODS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
144
Recensione:
Indirizzi per estratti:
Indirizzo: Simpkins, CO Nassau Cty Med Ctr, 2201 Hempstead Tpke, E Meadow, NY 11554 USA Nassau Cty Med Ctr 2201 Hempstead Tpke E Meadow NY USA 11554
Citazione:
C.O. Simpkins, "Metallothionein in human disease", CELL MOL B, 46(2), 2000, pp. 465-488

Abstract

Evidence concerning a role for metallothionein (MT) in human disease is reviewed. Current knowledge of MT is juxtaposed with our understanding of thepathogenesis of disease. MT is known to modulate three fundamental processes: 1) the release of gaseous mediators such as hydroxyl radical or nitric oxide; 2) apoptosis, and 3) the binding and exchange of heavy metals such as zinc, cadmium or copper. The capability to specifically manipulate MT levels in cells and in mice is beginning to provide answers regarding how MT could impact complex disease scenarios. Associations among MT and several diseases, including cancer, circulatory and septic shock, coronary artery disease, and Alzheimer's disease have been made. Strong evidence exists that MT modulates the immune system. The primary function of MT remains unknown.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:14:04