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Titolo:
Toxicological aspects of metallothionein
Autore:
Nordberg, M; Nordberg, GF;
Indirizzi:
Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Med, S-17177 Stockholm, Sweden Umea Univ, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187Umea Univ, S-90187 Umea, Sweden
Titolo Testata:
CELLULAR AND MOLECULAR BIOLOGY
fascicolo: 2, volume: 46, anno: 2000,
pagine: 451 - 463
SICI:
0145-5680(200003)46:2<451:TAOM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-TRANSGENIC MICE; CADMIUM-METALLOTHIONEIN; INDUCED NEPHROTOXICITY; TUBULE CELLS; HUMAN KIDNEY; RATS; BRAIN; ZINC; EXPRESSION; INDUCTION;
Keywords:
organ; metals; metallothionein; toxicokinetics; biochemistry;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Nordberg, M Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 7 Stockholm, Sweden
Citazione:
M. Nordberg e G.F. Nordberg, "Toxicological aspects of metallothionein", CELL MOL B, 46(2), 2000, pp. 451-463

Abstract

Metallothionein (MT) is expressed to a certain extent in almost all mammalian tissues. The biological significance of MT is related to its various forms MT-1, MT-2, MT-3 and MT-4, For MT-I several isoforms of the protein exist and it is likely that these isoforms are related to various functions involved in developmental processes occurring at various stages of gestation. Toxicokinetics and biochemistry of essential and toxic metals such as cadmium, zinc, mercury and copper in organs e.g. kidney, CNS, are often relatedto metallothionein, It is debated whether there is a relation or not for other metals e.g. selenium and bismuth. For the toxicokinetics of cadmium, MT plays an important role. By expanding techniques from experimental toxicology and biochemistry to include molecular biology methods, more specific and relevant studies can be performed of the actual role and biological function of MT. The present paper on toxicological aspects of metallothionein, presents an overview and evaluation of present knowledge concerning differences among organs and within organs of the expression of MT and how this affects tissue sensitivity to toxicity.

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Documento generato il 30/11/20 alle ore 07:08:47