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Titolo:
Metallothioneins in marine mammals.
Autore:
Das, K; Debacker, V; Bouquegneau, JM;
Indirizzi:
Univ Liege, Dept Oceanog, B-4000 Liege, Belgium Univ Liege Liege BelgiumB-4000 ege, Dept Oceanog, B-4000 Liege, Belgium
Titolo Testata:
CELLULAR AND MOLECULAR BIOLOGY
fascicolo: 2, volume: 46, anno: 2000,
pagine: 283 - 294
SICI:
0145-5680(200003)46:2<283:MIMM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CADMIUM-METALLOTHIONEIN; MONODON-MONOCEROS; METAL REGULATION; HEAVY-METALS; MERCURY; SELENIUM; BINDING; KIDNEY; LIVER; NEPHROTOXICITY;
Keywords:
metallothioneins; marine mammals; cadmium; mercury;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Bouquegneau, JM Univ Liege, Dept Oceanog, B6 Sart Tilman, B-4000 Liege, Belgium Univ Liege B6 Sart Tilman Liege Belgium B-4000 e, Belgium
Citazione:
K. Das et al., "Metallothioneins in marine mammals.", CELL MOL B, 46(2), 2000, pp. 283-294

Abstract

Metallothioneins (MTs) have been detected in livers and kidneys of 10 marine mammals species (Pinnipeds and Odontocetes). Characterization of renal MTs of striped dolphin has shown that the protein has two isoforms (MT-I andMT-2) with a molecular weight estimated around 6800, MT concentrations also vary widely in marine mammals tissues (from 58 to 1200 mu g.g(-1) ww) underlying the numerous parameters involved: physiological status, pregnancy, age, diet. The participation of this protein in metal detoxification has been investigated since high levels of cadmium (Cd) and mercury (Hg) have been measured in livers and kidneys of marine mammals, It has been suggested that those animals can mitigate at least in part, the toxic effects of Cd and Hg through binding to MTs. The percentage of the cytosolic Cd bound to MTs can reach almost 100%. On the contrary, the percentage of hepatic and renal Hg bound to MT is very low (generally less than 10%) and this metal is mainly associated with selenium (HgSe) under a detoxified form in the insoluble fraction of the tissues. MTs appear to play a minor role in the bindingand detoxification of Hg by marine mammals. On the contrary, close and dynamic interactions occur between Cd and MTs. Cytosolic MTs appear as a potential short term way of detoxification of Cd accumulated from diet. Long-term detoxification would imply a sequestration of the metal under a precipitated form (e.g. in lysosomes).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:13:36