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Titolo:
Increased levels of basic fibroblast growth factor are found in the cross-clamped heart during cardiopulmonary bypass
Autore:
Abramov, D; Erez, E; Dagan, O; Abramov, Y; Pearl, E; Veena, G; Katz, J; Vidne, BA; Barak, V;
Indirizzi:
Tel Aviv Univ, Dept Cardiothorac Surg, Rabin Med Ctr, IL-49100 Petah Tiqwa, Israel Tel Aviv Univ Petah Tiqwa Israel IL-49100 , IL-49100 Petah Tiqwa, Israel
Titolo Testata:
CANADIAN JOURNAL OF CARDIOLOGY
fascicolo: 3, volume: 16, anno: 2000,
pagine: 313 - 318
SICI:
0828-282X(200003)16:3<313:ILOBFG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBENDOTHELIAL EXTRACELLULAR-MATRIX; ENDOTHELIAL-CELLS; DEGRADATION; MYOCARDIUM; HEPARIN; RAT; LOCALIZATION; INFARCTION; INVASION; SULFATE;
Keywords:
cardiopulmonary bypass; growth substances;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Abramov, D 13 Shai Agnon St,POB 4241, Jerusalem, Israel 13 Shai Agnon St,POB 4241 Jerusalem Israel Jerusalem, Israel
Citazione:
D. Abramov et al., "Increased levels of basic fibroblast growth factor are found in the cross-clamped heart during cardiopulmonary bypass", CAN J CARD, 16(3), 2000, pp. 313-318

Abstract

BACKGROUND: High concentrations of fibroblast growth factors (FGFs) are found in the heart. Even higher levels are measured during ischemia. Exogenous administration of FGF to ischemic myocardium promotes synthesis of collateral coronary circulation and induces local myocardial hypertrophy. The kinetics and the contribution of the heart and lungs to circulating basic FGF (bFGF) levels during cardiac surgery were characterized. PATIENTS AND METHODS: Plasma bFGF levels were measured in seven adults undergoing coronary artery bypass operations and 11 neonates undergoing congenital cardiac anomaly repair during cardiopulmonary bypass. RESULTS: In both the adult and the neonatal groups, bFGF plasma levels increased significantly immediately after removal of the aortic cross-clamp (adult group 15.43 +/- 6.3 aorta cross clamped versus 29 +/- 4.1 after release, P = 0.011; neonatal group 17.09 +/- 9.43 aorta cross-clamped versus 43.55 +/- 14.25 after release, P = 0.004) and declined thereafter. In the adultgroup, higher levels of bFGF were recorded in blood recovered from the coronary sinus than in the aortic root during aortic cross clamping (63.14 +/-14.42 versus 43.86 +/- 12.05, P = 0.011), and in both, levels were significantly higher than the peripheral measurements. CONCLUSIONS: Plasma bFGF levels increase during cardiopulmonary bypass. The source of this elevation is the lungs and heart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 19:20:07