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Titolo:
Parvovirus B19 infection: association with third-trimester intrauterine fetal death
Autore:
Skjoldebrand-Sparre, K; Tolfvenstam, T; Papadogiannakis, N; Wahren, B; Broliden, K; Nyman, M;
Indirizzi:
Huddinge Univ Hosp, Karolinska Inst, Dept Clin Virol, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 rol, S-14186 Huddinge, Sweden Huddinge Univ Hosp, Karolinska Inst, Dept Pathol, S-14186 Huddinge, SwedenHuddinge Univ Hosp Huddinge Sweden S-14186 hol, S-14186 Huddinge, Sweden Danderyd Hosp, Karolinska Inst, Div Obstet & Gynaecol, Stockholm, Sweden Danderyd Hosp Stockholm Sweden Div Obstet & Gynaecol, Stockholm, Sweden Karolinska Inst, Dept Clin Virol, Swedish Inst Infect Dis Control, Microbiol & Tumourbiol Ctr, Stockholm, Sweden Karolinska Inst Stockholm Sweden ol & Tumourbiol Ctr, Stockholm, Sweden
Titolo Testata:
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 4, volume: 107, anno: 2000,
pagine: 476 - 480
SICI:
1470-0328(200004)107:4<476:PBIAWT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROPS-FETALIS; VIRAL-INFECTION; PREGNANCY; SECONDARY; HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Broliden, K Huddinge Univ Hosp, Karolinska Inst, Dept Clin Virol, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 Huddinge, Sweden
Citazione:
K. Skjoldebrand-Sparre et al., "Parvovirus B19 infection: association with third-trimester intrauterine fetal death", BR J OBST G, 107(4), 2000, pp. 476-480

Abstract

Objective To identify the presence of parvovirus B19 infection as a possible cause of fetal loss in the third trimester. Design Prospective study of women experiencing third-trimester intrauterine fetal death (IUFD). Setting All cases of IUFD at Danderyd Hospital from 1992 to 1998. Population Ninety-three women with IUFD in 33,759 deliveries (0.3%). Methods Detection of B19 DNA by polymerase chain reaction (PCR) in placental and fetal tissue. Placental pathology and B19-specific immunohistochemistry. Maternal serology in consecutive samples. Results Among 93 cases of IUFD, seven (7.5%) had detectable B19 DNA in freshly-frozen placental tissue. The detection of B19 DNA in these tissues wasconfirmed by detection of B19 DNA in six separately stored paraffin-embedded placental tissues. No other explanations for the fetal deaths were found. None of the women had experienced any clinical signs of infection prior to fetal demise. None of the seven fetuses were hydropic. Histopathologic examination of the placentas revealed only minor abnormalities. Serology on maternal samples at birth revealed delayed or absent B19 IgG responses in five of seven cases. Two women were B19 IgG seropositive at the time of delivery but had unusual infection patterns; persistent viraemia for at least five months before birth in one case and likely persistence or re-infection by B19 in the other. Conclusion In our study, 7.5% of IUFDs in the third trimester may have been caused by parvovirus B19 infection, without signs of fetal hydrops. This finding indicates that B19 PCR should be included in the routine investigation of IUFD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 02:58:42