Catalogo Articoli (Spogli Riviste)

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Titolo:
Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis
Autore:
Kim, I; Kim, HG; Kim, H; Kim, HH; Park, SK; Uhm, CS; Lee, ZH; Koh, GY;
Indirizzi:
Chonbuk Natl Univ, Sch Med, Natl Creat Res Initiat Ctr Cardiac Regenerat, Chonju 560180, South Korea Chonbuk Natl Univ Chonju South Korea 560180 , Chonju 560180, South Korea Chonbuk Natl Univ, Sch Med, Cardiovasc Res Inst, Chonju 560180, South Korea Chonbuk Natl Univ Chonju South Korea 560180 , Chonju 560180, South Korea Chonbuk Natl Univ, Sch Med, Dept Internal Med, Chonju 560180, South Korea Chonbuk Natl Univ Chonju South Korea 560180 , Chonju 560180, South Korea Korea Univ, Grad Sch Biotechnol, Seoul 136705, South Korea Korea Univ Seoul South Korea 136705 iotechnol, Seoul 136705, South Korea Korea Univ, Inst Human Genet, Dept Anat, Seoul 136705, South Korea Korea Univ Seoul South Korea 136705 Dept Anat, Seoul 136705, South Korea Chosun Univ, Sch Dent, Dept Microbiol & Immunol, Kwangju 501759, South Korea Chosun Univ Kwangju South Korea 501759 unol, Kwangju 501759, South Korea
Titolo Testata:
BIOCHEMICAL JOURNAL
, volume: 346, anno: 2000,
parte:, 3
pagine: 603 - 610
SICI:
0264-6021(20000315)346:<603:HESASO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASE; MOLECULAR-CLONING; TIE2 RECEPTOR; ANGIOGENESIS; FIBRINOGEN; ANGIOPOIETIN-1; SEQUENCE; DOMAINS; LIGAND;
Keywords:
endocrine; liver; Tie receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Koh, GY Chonbuk Natl Univ, Sch Med, Natl Creat Res Initiat Ctr Cardiac Regenerat, Chonju 560180, South Korea Chonbuk Natl Univ Chonju South Korea 560180 560180, South Korea
Citazione:
I. Kim et al., "Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis", BIOCHEM J, 346, 2000, pp. 603-610

Abstract

Using degenerate PCR we isolated a cDNA encoding a novel 406- and 410-amino acid protein from human and mouse embryonic cDNAs and have designated it 'hepatic fibrinogen/ angiopoietin-related protein' (HFARP). The N-terminal and C-terminal portions of HFARP contain the characteristic coiled-coil domains and fibrinogen-like domains that are conserved in angiopoietins. In human and mouse tissues, HFARP mRNA is specifically expressed in the liver. HFARP mRNA and protein are mainly present in the hepatocytes. HFARP has a highly hydrophobic region at the N-terminus that is typical of a secretory signal sequence and one consensus glycosylation site. Recombinant HFARP expressed in COS-7 cells is secreted and glycosylated. HFARP protein is present not only in the hepatocytes, but also in the circulating blood. RecombinantHFARP acts as an apoptosis survival factor for vascular endothelial cells,but does not bind to Tie1 or Tie2 (endothelial-cell tyrosine kinase receptors). These results suggest that HFARP may exert a protective function on endothelial cells through an endocrine action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 16:37:36