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Titolo:
Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease
Autore:
Lipsky, PE; Brooks, P; Crofford, LJ; DuBois, R; Graham, D; Simon, LS; van de Putte, LBA; Abramson, SB;
Indirizzi:
Univ Texas, SW Med Ctr, Div Rheumat Dis, Arthritis Res Ctr, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 s, Arthritis Res Ctr, Dallas, TX 75235 USA Univ Queensland, Brisbane, Qld, Australia Univ Queensland Brisbane Qld Australia ensland, Brisbane, Qld, Australia Univ Michigan, Ctr Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 an, Ctr Med, Ann Arbor, MI 48109 USA Vanderbilt Univ, Ctr Med, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 , Ctr Med, Nashville, TN 37232 USA Vet Affairs Med Ctr, Houston, TX 77030 USA Vet Affairs Med Ctr Houston TXUSA 77030 s Med Ctr, Houston, TX 77030 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Univ Nijmegen Hosp, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp Nijmegen Netherlands NL-6500 HB Nijmegen, Netherlands NYU, Sch Med, New York, NY USA NYU New York NY USANYU, Sch Med, New York, NY USA
Titolo Testata:
ARCHIVES OF INTERNAL MEDICINE
fascicolo: 7, volume: 160, anno: 2000,
pagine: 913 - 920
SICI:
0003-9926(20000410)160:7<913:UIITRO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PERIIMPLANTATION MOUSE UTERUS; PROSTAGLANDIN G/H SYNTHASE-1; ACUTE-RENAL-FAILURE; ASPIRIN-LIKE DRUGS; ALZHEIMERS-DISEASE; COLORECTAL-CANCER; GASTROINTESTINAL-TRACT; ARACHIDONIC-ACID; GENE-EXPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Lipsky, PE Univ Texas, SW Med Ctr, Div Rheumat Dis, Arthritis Res Ctr, 5323 Harry Hines Blvd, Dallas, TX 75235 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75235 75235 USA
Citazione:
P.E. Lipsky et al., "Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease", ARCH IN MED, 160(7), 2000, pp. 913-920

Abstract

Originally suggested to function mainly in inflammatory situations, recentdata have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:10:37