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Titolo:
Serum levels of interleukin-12 in patients with gastrointestinal cancer
Autore:
Nakayama, Y; Shibao, K; Sako, T; Ohta, R; Onitsuka, K; Hirata, K; Nagata, N; Itoh, H;
Indirizzi:
Univ Occupat & Environm Hlth, Dept Surg 1, Yahata Nishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan8078555 8555, Japan
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 1C, volume: 20, anno: 2000,
pagine: 635 - 640
SICI:
0250-7005(200001/02)20:1C<635:SLOIIP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT HUMAN INTERLEUKIN-12; BLOOD MONONUCLEAR-CELLS; IFN-GAMMA PRODUCTION; T RESPONSES INVITRO; IMMUNE-RESPONSE; IN-VIVO; TUMOR-REGRESSION; INTERFERON-GAMMA; TH2 CELLS; CYTOKINE;
Keywords:
interleukin-12; gastric cancer; colorectal cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Nakayama, Y Univ Occupat & Environm Hlth, Dept Surg 1, Yahata Nishi Ku, 1-1 Iseigaoka,Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth1-1 Iseigaoka Kitakyushu Fukuoka Japan 8078555
Citazione:
Y. Nakayama et al., "Serum levels of interleukin-12 in patients with gastrointestinal cancer", ANTICANC R, 20(1C), 2000, pp. 635-640

Abstract

Interleukin 12(IL-12) is a heterodimeric cytokine that has potent anti-tumor and anti-metastatic activities. Although clinical trials of recombinant human IL-12 have begun in patients with several advanced malignancies, veryfew studies have investigated the preoperative serum levels of IL-12 in patients with gastric or. colorectal cancel: The purpose of the present studywas to investigate the relationships between the preoperative serum levelsof IL-12 and clinicopathological factors in patients with gastric ol colorectal cancer Blood was obtained before surgery from 14 patients with gastric cancer a,ld 15 patients with colorectal cancer Serum levels of IL-12 was assesed using the quantitative sandwich enzyme immunoassay technique. Although not statistically significantly; low serum levels of IL-12 tended to beassociated with gastric cancer patients who were node-positive, CEA positive, han tumors that penetrated the serosa, had turners greater than 5cm in diameter; were more than 60 years-old or were more advanced than stage IIIA(TNM) or stage IIIa(Japanese Research Society for Gastric Cancer). Patientswith colorectal cancer who were node-positive, had tumors that penetrated the serosa, were mole than 60 years-old, or were more advanced than stage III(TNM), stage IIIa (Japanese Society for Cancel of the Colon and Rectum) and Dukes' C also tended to have low serum IL-12 levels. these results suggest that low serum levels of IL-12 may be observed in more advanced gastric and cob-ectal cancer patients. Thus, patients with low serum levels of IL-12 in gastric or colorectal cancer ma)! require additional immunochemotherapy after surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:15:25