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Titolo:
Clinical disease in kittens inoculated with a pathogenic strain of Bartonella henselae
Autore:
Mikolajczyk, MG; OReilly, KL;
Indirizzi:
Louisiana State Univ, Sch Vet Med, Dept Vet Microbiol & Parasitol, Baton Rouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 , Baton Rouge, LA 70803 USA
Titolo Testata:
AMERICAN JOURNAL OF VETERINARY RESEARCH
fascicolo: 4, volume: 61, anno: 2000,
pagine: 375 - 379
SICI:
0002-9645(200004)61:4<375:CDIKIW>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAT-SCRATCH-DISEASE; BACILLARY ANGIOMATOSIS; EXPERIMENTAL-INFECTION; ENDOGENOUS PYROGEN; DOMESTIC CATS; ROCHALIMAEA; INTERLEUKIN-1; TRANSMISSION; BACTEREMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: O'Reilly, KL Louisiana State Univ, Sch Vet Med, Dept Vet Microbiol & Parasitol, Baton Rouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 , LA 70803 USA
Citazione:
M.G. Mikolajczyk e K.L. O'Reilly, "Clinical disease in kittens inoculated with a pathogenic strain of Bartonella henselae", AM J VET RE, 61(4), 2000, pp. 375-379

Abstract

Objective-To evaluate disease in kittens inoculated with Bartonella henselae strain LSU16. Animals-Eighteen 12-week-old specific-pathogen-free kittens. Procedure-Kittens were inoculated with B henselae strain LSU16 or saline (0.9% NaCl) solution. Blood samples were collected from kittens on alternateweeks, and bacteremia, clinical signs, and antibody concentrations were monitored for 6 months after inoculation. Results-Kittens developed raised, erythematous areas at the site of inoculation within 72 hours. Swelling peaked at 14 days and resolved by 28 days after inoculation. Fever had a biphasic pattern, with an episode of 1- to 3-days' duration beginning 6 tol days after inoculation followed by an episode of 3- to 8-days' duration beginning 11 to 13 days after inoculation. Kittens were bacteremic by day 14 with peak bacteremia at days 14 to 28. Strongantibody responses to B henselae were detected. Clinical disease resolved before bacteremia became undetectable, but signs of disease correlated withthe highest degree of bacteremia. Regional lymphadenopathy also was evident. Conclusion and Clinical Relevance-Clinical disease in kittens was similar to that in adult cats infected with B henselae strain LSU16, except that lethargy and anorexia were less severe in kittens, and a biphasic pattern of fever was detected in kittens. Clinical disease after inoculation with B henselae may be strain-dependent. To limit transmission of Bartonella organisms, appropriate flea prevention should be instituted. Impact for Human Medicine-Kittens that are febrile, anorectic, lethargic, and that have lymphadenopathy should be tested for Bartonella organisms, and contact with immunocompromised owners should be discouraged.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 01:31:02