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Titolo:
Apoptotic mechanisms in acute renal failure
Autore:
Ueda, N; Kaushal, GP; Shah, SV;
Indirizzi:
Univ Arkansas Med Sci Hosp, Dept Med, Div Nephrol, Little Rock, AR 72205 USA Univ Arkansas Med Sci Hosp Little Rock AR USA 72205 le Rock, AR 72205 USA Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA Cent Arkansas Vet Healthcare Syst Little Rock AR USA Little Rock, AR USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICINE
fascicolo: 5, volume: 108, anno: 2000,
pagine: 403 - 415
SICI:
0002-9343(20000401)108:5<403:AMIARF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCYTE GROWTH-FACTOR; HEMOLYTIC-UREMIC SYNDROME; TUBULAR EPITHELIAL-CELLS; CISPLATIN-INDUCED APOPTOSIS; DNA FRAGMENTATION; LLC-PK1 CELLS; C-FOS; INTERLEUKIN-1-BETA-CONVERTING ENZYME; ISCHEMIA-REPERFUSION; POSSIBLE INVOLVEMENT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
127
Recensione:
Indirizzi per estratti:
Indirizzo: Ueda, N Univ Arkansas Med Sci Hosp, Dept Med, Div Nephrol, 4301 W Markham,Slot 501, Little Rock, AR 72205 USA Univ Arkansas Med Sci Hosp 4301 W Markham,Slot 501 Little Rock AR USA 72205
Citazione:
N. Ueda et al., "Apoptotic mechanisms in acute renal failure", AM J MED, 108(5), 2000, pp. 403-415

Abstract

It has been generally accepted that a catastrophic breakdown of regulated cellular homeostasis, known as necrosis, is the mode of cellular injury in various forms of acute renal failure. One of the major advances in our understanding of cell death has been the recognition that the pathways traditionally associated with apoptosis as described in the landmark study by Kerr,Wyllie, and Currie in 1972 may be very critical in the form of cell injuryassociated with necrosis. The pathway that is followed by the cell varies with both nature and severity of insults and may evolve from an apoptotic to a necrotic form of cell death. It is also likely that there are some common pathways that are shared and regulated in the two modes of cell death. In this review, we first describe evidence for the role of apoptotic pathways in ischemic acute renal failure, and then consider the potential mechanisms that may participate in this model of acute renal tubular injury. We then summarize the current information of apoptotic pathways related to other common causes of acute renal failure including endotoxin-induced, toxic acute renal failure and transplant rejection. A better understanding of the mechanisms of apoptosis could lead to safer and more specific therapeutic interventions for acute renal failure. Am J Med. 2000;108: 403-415. (C) 2000 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:04:20