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Titolo:
The effect of ammonia on omeprazole-induced reduction of gastric acidity in subjects with Helicobacter pylori infection
Autore:
Bercik, P; Verdu, EF; Armstrong, D; Idstrom, JP; Cederberg, C; Markert, M; Crabtree, JE; Stolte, M; Blum, AL;
Indirizzi:
McMaster Univ, Intestinal Dis Res Programme, Div Gastroenterol, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 ol, Hamilton, ON L8N 3Z5, Canada CHUV, Div Gastroenterol, Lausanne, Switzerland CHUV Lausanne Switzerland HUV, Div Gastroenterol, Lausanne, Switzerland CHUV, Cent Lab Clin Chem, Lausanne, Switzerland CHUV Lausanne Switzerland UV, Cent Lab Clin Chem, Lausanne, Switzerland Astra Hassle AB, Dept Clin Pharmacol, Molndal, Sweden Astra Hassle AB Molndal Sweden AB, Dept Clin Pharmacol, Molndal, Sweden Klinikum Bayreuth, Inst Pathol, Bayreuth, Germany Klinikum Bayreuth Bayreuth Germany euth, Inst Pathol, Bayreuth, Germany Univ Leeds, St James Hosp, Dept Med, Leeds LS9 7TF, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS9 7TF S9 7TF, W Yorkshire, England
Titolo Testata:
AMERICAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 4, volume: 95, anno: 2000,
pagine: 947 - 955
SICI:
0002-9270(200004)95:4<947:TEOAOO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAGASTRIC PH; DUODENAL-ULCER; SERUM GASTRIN; BREATH TEST; SECRETION; INHIBITION; UREASE; ERADICATION; HISTOLOGY; OUTPUT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Bercik, P McMaster Univ, Intestinal Dis Res Programme, Div Gastroenterol, 1200 Main St W, Hamilton, ON L8N 3Z5, Canada McMaster Univ 1200 Main St W Hamilton ON Canada L8N 3Z5 , Canada
Citazione:
P. Bercik et al., "The effect of ammonia on omeprazole-induced reduction of gastric acidity in subjects with Helicobacter pylori infection", AM J GASTRO, 95(4), 2000, pp. 947-955

Abstract

OBJECTIVE: Omeprazole produces a higher intragastric pH during Helicobacter pylori (H. pylori) infection than after cure. We tested the hypothesis that this difference is due to the production of ammonia by H. pylori. METHODS: Gastric acidity and acid output (AO) were measured overnight in 12 subjects, with and without omeprazole, before and 1 and 6 months after cure of H. pylori infection. Gastric ammonia ([NH3]), total bile acid ([TBA])and protein concentrations and plasma omeprazole levels were measured. RESULTS: During omeprazole, median AO were 0.0 mmol/h before, 0.86 mmol/h (p = 0.003 vs before cure) at 1 month, and 0.34 mmol/h (p = 0.02) at 6 months after cure; median NH3 output was 0.17 mmol/h before, 0.03 mmol/h (p = 0.002) at 1 month, and 0.02 mmol/h (p = 0.005) at 6 months after cure. AO and NH3 output were similar 1 and 6 months after cure. When corrected for [NH3], AO and gastric pH curves were similar before and after cure. Omeprazoleplasma levels increased after cure and gastric [TBA] were unchanged. CONCLUSIONS: The higher pH observed before cure of H. pylori during omeprazole administration is attributable, in large part, to ammonia production. Other acid-neutralizing substances and changes in acid secretion may also be important, but duodenogastric reflux and omeprazole pharmacokinetics are not involved. (C) 2000 by Am. Cell. of Gastroenterology.

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Documento generato il 14/07/20 alle ore 19:31:39