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Titolo:
Estimation of adverse drug reactions by the evaluation scores of subjective symptoms (complaints) and background of patients. III. Drug-induced leucopenia
Autore:
Ohtsu, F; Yano, R; Inagaki, K; Sakakibara, J;
Indirizzi:
Meijo Univ, Fac Pharm, Pharmaceut Informat Ctr, Tempaku Ku, Nagoya, Aichi 4688503, Japan Meijo Univ Nagoya Aichi Japan 4688503 ku Ku, Nagoya, Aichi 4688503, Japan
Titolo Testata:
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
fascicolo: 4, volume: 120, anno: 2000,
pagine: 397 - 407
SICI:
0031-6903(200004)120:4<397:EOADRB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED AGRANULOCYTOSIS;
Keywords:
adverse drug reaction; evaluation score; drug-induced leucopenia; database;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Sakakibara, J Meijo Univ, Fac Pharm, Pharmaceut Informat Ctr, Tempaku Ku, 150 Yagotoyama, Nagoya, Aichi 4688503, Japan Meijo Univ 150 Yagotoyama Nagoya Aichi Japan 4688503 , Japan
Citazione:
F. Ohtsu et al., "Estimation of adverse drug reactions by the evaluation scores of subjective symptoms (complaints) and background of patients. III. Drug-induced leucopenia", YAKUGAKU ZA, 120(4), 2000, pp. 397-407

Abstract

Objectives: The purpose of this study was to develop, implement, and assess an estimation procedure for preventing adverse drug reaction by subjective symptoms (complaints) of patients. This time, we carried out this study focusing on drug-induced leucopenia. Methods: We have built a database for CARPIS (Case Reports of Adverse DrugReaction and Poisoning Information System) since 1987, and the total number of case reports of adverse drug reaction accumulated in the CARPIS database amounts to about 16000. Using the date obtained from 139 cases of drug-induced leucopenia accumulated in the CARPIS database, we investigated a relationship between leucopenia and patients. The evaluation scores were created based on the subjective symptoms and backgrounds of the patients. Results: We could estimate 91 cases (65.5%) in 139 cases to be drug-induced leucopenia by the use of these evaluation scores. The validity of this evaluation scores was estimated to be as follows; sensitivity = 65.5%, specificity = 80.0% and predictive value of positive test (PVP) = 82.0%. The positive likelihood (LR) ratio was 3.3 and negative likelihood ratio 0.43. Conclusions: In this study, PVP and LR values were not good, because amongthe symptoms of leucopenia a very few specific symptoms could be detected. But we reported previous by the evaluation scores about drug-induced liverdisorders. Therefore, in order to apply these evaluation scores to the clinical practice, we prepared an evaluation form for subjective symptoms and backgrounds of the patients with adverse drug reactions. In the future, we plan to examine other adverse reactions which adds the data to this form.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:55:56