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Titolo:
Cell surface expression of immature H glycoprotein in measles virus-infected cells
Autore:
Ogura, H; Matsunaga, I; Takano, Y; Ning, XJ; Ayata, M; Tanaka, K; Seto, T; Furukawa, K; Ito, N; Shingai, M; Kimura, T; Ichihara, K; Kubo, H; Murakami, T;
Indirizzi:
Osaka City Univ, Sch Med, Dept Virol, Abeno Ku, Osaka 5458585, Japan OsakaCity Univ Osaka Japan 5458585 irol, Abeno Ku, Osaka 5458585, Japan Osaka City Univ, Sch Med, Dept Mol Regulat, Abeno Ku, Osaka 5458585, JapanOsaka City Univ Osaka Japan 5458585 ulat, Abeno Ku, Osaka 5458585, Japan Osaka City Univ, Sch Med, Dept Pediat, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 diat, Abeno Ku, Osaka 5458585, Japan Osaka City Inst Publ Hlth & Environm Sci, Tennouji Ku, Osaka 5458585, Japan Osaka City Inst Publ Hlth & Environm Sci Osaka Japan 5458585 8585, Japan
Titolo Testata:
VIRUS RESEARCH
fascicolo: 2, volume: 66, anno: 2000,
pagine: 187 - 196
SICI:
0168-1702(200002)66:2<187:CSEOIH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMAGGLUTININ PROTEIN; DOWN-REGULATION; FUSION PROTEIN; MEMBRANE; CD46; RECEPTOR; BINDING; GLYCOSYLATION; PROTECTION; EPITOPES;
Keywords:
measles virus; immature H protein; cell surface expression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ogura, H Osaka City Univ, Sch Med, Dept Virol, Abeno Ku, Asahimachi 1-4-3,Osaka 5458585, Japan Osaka City Univ Asahimachi 1-4-3 Osaka Japan 54585858585, Japan
Citazione:
H. Ogura et al., "Cell surface expression of immature H glycoprotein in measles virus-infected cells", VIRUS RES, 66(2), 2000, pp. 187-196

Abstract

Two forms of hemagglutinin (H) protein, one with an apparent molecular mass of 78 kDa (78K H protein) and the other with that of 74 kDa (74K H protein), are present in cells infected with measles virus (MV). We previously observed that only the mature 78K H protein, a completely glycosylated form of the 74K H protein, was expressed on the cell surface of the infected cells. In the present study, we detected transient expression of the 74K H protein on the cell surface of infected cells by pulse-chase studies, although the level of this expression was much lower than that of the 78K H protein. On the cell surface the 74K H protein was present as dimers and sensitive to endo-beta-N-acetylglucosaminidase H digestion. Treatment with brefeldin A, which blocks the transport of membrane and secretory proteins from the endoplasmic reticulum to the Golgi apparatus, inhibited the cell surface expression of the 78K H protein, but not that of the 74K H protein. These datasuggest that a part of the MV 74K H proteins could be transported directlyto the cell surface - probably via an alternative pathway - without processing to the complex form in the Golgi apparatus. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 11:21:39