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Titolo:
Fusion of uninfected T-cells occurs with immature HIV-1 protease-mutant, but not morphologically similar protease inhibitor derived particles
Autore:
Bahmani, MK; Kameoka, M; Goto, T; Sano, K; Luftig, RB; Ikuta, K;
Indirizzi:
Hokkaido Univ, Inst Immunol Sci, Sect Serol, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 ol, Sapporo, Hokkaido 060, Japan Osaka Med Coll, Dept Microbiol, Takatsuki, Osaka 569, Japan Osaka Med Coll Takatsuki Osaka Japan 569 iol, Takatsuki, Osaka 569, Japan Louisiana State Univ, Med Ctr, Dept Microbiol Immunol & Parasitol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA
Titolo Testata:
VIRUS RESEARCH
fascicolo: 2, volume: 66, anno: 2000,
pagine: 131 - 137
SICI:
0168-1702(200002)66:2<131:FOUTOW>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; PERSISTENTLY INFECTED-CELLS; ACCESSORY GENE-MUTATIONS; SERIAL PASSAGE; VPU MUTANTS; MT-4 CELLS; WILD-TYPE; APOPTOSIS; LATENT; AIDS;
Keywords:
HIV; protease inhibitor; doughnut-shaped particle; syncytia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Ikuta, K Osaka Univ, Dept Virol, Res Inst Microbial Dis, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
M.K. Bahmani et al., "Fusion of uninfected T-cells occurs with immature HIV-1 protease-mutant, but not morphologically similar protease inhibitor derived particles", VIRUS RES, 66(2), 2000, pp. 131-137

Abstract

Protease inhibitors are widely used in the treatment of human immunodeficiency virus type 1 (HIV-1)-infected individuals and show a drastic effect onthe reduction of virus load. We previously reported that doughnut-shaped, protease-defective gp120-containing HIV-1 particles from an L-2 cell clone,carrying a provirus with mutations at the pol (protease), env (gp41) and nef genes, rapidly and more effectively induces virus particle-mediated syncytia formation of uninfected T-cells, than a parental wild-type laboratory strain of HIV-1 (LAI). In this study, we examined the possibility of whether enhanced syncytia formation is mediated by morphologically similar doughnut-shaped particles obtained after treatment of LAI-infected cells with theprotease inhibitors L-689,502, DMP-323, RO-31-8959, and KNI-272. Utilizingsuch protease inhibitor-induced particles and a clone of MOLT-4 cells, we could not detect any enhancement of syncytia formation, over that seen withwild-type LAI particles. This result should alleviate concerns of patientson highly active antiretroviral therapy (HAART), that protease inhibitors might accelerate progression of the disease through enhanced production of defective, 'immature'-appearing particles. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:57:09