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Titolo:
Chromate-induced human erythrocytes haemoglobin oxidation and peroxidation: influence of vitamin E, vitamin C, salicylate, deferoxamine, and N-ethylmaleimide
Autore:
Fernandes, MAS; Geraldes, CFGC; Oliveira, CR; Alpoim, MC;
Indirizzi:
Univ Coimbra, Fac Ciencias, Dept Zool, P-3004517 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3004517 ool, P-3004517 Coimbra, Portugal Univ Coimbra, Fac Ciencias, Dept Bioquim, P-3001401 Coimbra, Portugal UnivCoimbra Coimbra Portugal P-3001401 uim, P-3001401 Coimbra, Portugal Univ Coimbra, Fac Med, Serv Bioquim, P-3004504 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3004504 uim, P-3004504 Coimbra, Portugal
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1-3, volume: 114, anno: 2000,
pagine: 237 - 243
SICI:
0378-4274(20000403)114:1-3<237:CHEHOA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEXAVALENT CHROMIUM; LIPID-PEROXIDATION; RAT HEPATOCYTES; GLUTATHIONE-REDUCTASE; SODIUM CHROMATE(VI); SULFHYDRYL-GROUPS; PRIMARY CULTURES; CELLULAR INJURY; CYTOTOXICITY; DAMAGE;
Keywords:
antioxidants; chromate; cytotoxicity; haemoglobin oxidation; human erythrocytes; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandes, MAS Univ Coimbra, Fac Ciencias, Dept Zool, P-3004517 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3004517 Coimbra, Portugal
Citazione:
M.A.S. Fernandes et al., "Chromate-induced human erythrocytes haemoglobin oxidation and peroxidation: influence of vitamin E, vitamin C, salicylate, deferoxamine, and N-ethylmaleimide", TOX LETT, 114(1-3), 2000, pp. 237-243

Abstract

In order to attenuate or to prevent chromate-induced human erythrocytes injury, the influence of Vitamin E, vitamin C, salicylate, deferoxamine, and N-ethylmaleimide on chromate-induced human erythrocytes haemoglobin oxidation and peroxidation were investigated. It was observed that pretreatment ofhuman erythrocytes with vitamin E (20 mu M), vitamin C (1 mM), salicylate (3 mM), and deferoxamine (4 mM) significantly increased (P = 0.0001) chromate-induced human erythrocytes haemoglobin oxidation in a time dependent manner, while it was significantly decreased (P = 0.0001) by pretreatment withN-ethylmaleimide (1 mM). In contrast, pretreatment of human erythrocytes with deferoxamine (4 mM) immediately inhibited (P = 0.0001) chromate-inducedhuman erythrocytes peroxidation, while it was significantly increased (P =0.0001) by pretreatment with N-ethylmaleimide (1 mM) during the first 4 h of cells exposition to chromate. For time periods superior to 6 h pretreatment with N-ethylmaleimide (1 mM) significantly decreased (P = 0.0001) chromate-induced human erythrocytes peroxidation. It was concluded that care must be taken as these drugs are used to prevent against toxicity induced by chromium(VI) compounds. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 24/11/20 alle ore 14:35:15