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Titolo:
RHINOVIRUS INFECTION PREFERENTIALLY INCREASES LOWER AIRWAY RESPONSIVENESS IN ALLERGIC SUBJECTS
Autore:
GERN JE; CALHOUN W; SWENSON C; SHEN GH; BUSSE WW;
Indirizzi:
UNIV WISCONSIN HOSP,600 HIGHLAND AVE,H4-438 CSC MADISON WI 53792 UNIV WISCONSIN,DEPT MED MADISON WI 53706 UNIV WISCONSIN,DEPT PEDIAT MADISON WI 53706
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 6, volume: 155, anno: 1997,
pagine: 1872 - 1876
SICI:
1073-449X(1997)155:6<1872:RIPILA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN BRONCHOPROVOCATION; ASTHMATIC SUBJECTS; EXACERBATIONS; VIRUSES; HYPERREACTIVITY; INFLAMMATION; TRANSMISSION; PRECIPITANTS; CHILDREN; ADULTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Gern et al., "RHINOVIRUS INFECTION PREFERENTIALLY INCREASES LOWER AIRWAY RESPONSIVENESS IN ALLERGIC SUBJECTS", American journal of respiratory and critical care medicine, 155(6), 1997, pp. 1872-1876

Abstract

Rhinovirus (RV) infections are important triggers of acute asthma symptoms in susceptible persons. To determine whether the presence of allergy is a risk factor for enhanced lower airway effects during RV infection, we experimentally infected (RV16) 18 volunteers with allergic rhinitis and 13 normal control subjects and measured the effects on theresponse of the lower airways to histamine. All subjects were successfully infected, as indicated by increased upper respiratory symptoms and RV16 cultured from nasal secretions. The change in histamine PD20(Delta PD20) caused by RV infection was significantly different in allergic subjects from that in nonallergic control subjects (Delta PD20 = -0.40 versus -0.03 log units, p = 0.04). This relationship was strengthened after adjusting for initial PD20 and FEV1 (mean Delta PD20 = -0.43 versus 0.01 log units, p < 0.01). The virus-induced Delta PD20 was also influenced by baseline lung function: there was a positive correlation between initial FEV1 and Delta PD20, and a weak but significant negative correlation between baseline PD20 and Delta PD20. These findings indicate that host factors such as allergy, baseline FEV1, and baseline PD20 influence the changes in lower airway physiology caused by RV infection and raise the possibility that these factors contribute tothe increased lower airway effects of RV infection in subjects with asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 12:15:11