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Titolo:
Fine volumetric analysis of the cerebral ventricular system in schizophrenia: Further evidence for multifocal mild to moderate enlargement
Autore:
Sanfilipo, M; Lafargue, T; Arena, L; Rusinek, H; Kushner, K; Lautin, A; Loneragan, C; Vaid, G; Rotrosen, J; Wolkin, A;
Indirizzi:
VA New York Harbor Hlth Care System, Mental Hlth Serv 11M, New York, NY 10010 USA VA New York Harbor Hlth Care System New York NY USA 10010 k, NY 10010 USA Bellevue Hosp Ctr, New York, NY 10016 USA Bellevue Hosp Ctr New York NY USA 10016 Hosp Ctr, New York, NY 10016 USA NYU, Sch Med, New York, NY USA NYU New York NY USANYU, Sch Med, New York, NY USA Univ New S Wales, Kensington, NSW 2033, Australia Univ New S Wales Kensington NSW Australia 2033 ngton, NSW 2033, Australia
Titolo Testata:
SCHIZOPHRENIA BULLETIN
fascicolo: 1, volume: 26, anno: 2000,
pagine: 201 - 216
SICI:
0586-7614(2000)26:1<201:FVAOTC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRUCTURAL BRAIN ABNORMALITIES; COMPUTERIZED-TOMOGRAPHY; MORPHOLOGY; SIZE; DISORDER; HYPOTHESIS; RATIO; METAANALYSIS; PSYCHOSIS; STABILITY;
Keywords:
schizophrenia; cerebral ventricles; MRI; fine AP profile analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Wolkin, A VA New York Harbor Hlth Care System, Mental Hlth Serv 11M, Rm 17017W,423 E23rd St, New York, NY 10010 USA VA New York Harbor Hlth Care System Rm 17017W,423 E 23rd St New York NY USA 10010
Citazione:
M. Sanfilipo et al., "Fine volumetric analysis of the cerebral ventricular system in schizophrenia: Further evidence for multifocal mild to moderate enlargement", SCHIZO BULL, 26(1), 2000, pp. 201-216

Abstract

We used traditional volumetric regional analysis and a finer anterior-posterior (AP) profile volumetric analysis to examine the cerebral ventricular system in an all-male, demographically matched sample of schizophrenia patients (n = 73) and normal controls (n = 29) using 2.8-mm-thin coronal T-1-weighted magnetic resonance images from a 1.5 tesla scanner. Traditional regional analysis was performed on various regions using absolute volumes afteradjusting for intracranial volume (ICV) and age. The fine AP profile analysis was done by intrasubject "stacking" of contiguous coronal cross-sectional volumes (adjusted for ICV and age) across the AP plane, intersubject AP alignment of all slices relative to the mammillary bodies, and plotting of slice volumes along the AP plane with 95 percent t-test-based confidence intervals. Schizophrenia subjects had mild to moderate multifocal ventricularenlargement (overall effect size d = 0.48), which was especially prominentin the right posterior temporal horn and, more generally, in the central to posterior portions of the lateral and third ventricles. Schizophrenia subjects also had milder enlargement in the left frontal horn, but no significant differences were found in the anterior temporal horns and the right frontal horn. Post hoc analyses of demographic, clinical, and neuropsychological variables did not account for much variance in the ventriculomegaly observed in the schizophrenia group. The lack of a single locus in the observedventricular enlargement, the nonsignificant results from schizophrenia subtypes based on regional distributions, and the strong positive correlationsamong the ventricular regions for the schizophrenia group suggest that theventriculomegaly seen in this chronic population reflects a single brainwide disease process leading to a multifocal or patchy loss of integrity in brain structure.

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Documento generato il 21/09/20 alle ore 18:56:07