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Titolo:
Myocardial perfusion and intracapillary blood volume in rats at rest and with coronary dilatation: MR imaging in vivo with use of a spin-labeling technique
Autore:
Waller, C; Kahler, E; Hiller, KH; Hu, K; Nahrendorf, M; Voll, S; Haase, A; Ertl, G; Bauer, WR;
Indirizzi:
Univ Wurzburg, Inst Med, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 st Med, D-97080 Wurzburg, Germany Univ Wurzburg, Inst Phys, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 t Phys, D-97080 Wurzburg, Germany
Titolo Testata:
RADIOLOGY
fascicolo: 1, volume: 215, anno: 2000,
pagine: 189 - 197
SICI:
0033-8419(200004)215:1<189:MPAIBV>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERPARAMAGNETIC IRON-OXIDE; SNAPSHOT-FLASH MRI; COLORED MICROSPHERES; CONTRAST AGENTS; GD-DTPA; FLOW; T1; QUANTIFICATION; HEART; MICROCIRCULATION;
Keywords:
adenosine; blood, flow dynamics; blood, volume; heart, perfusion; magnetic resonance (MR), perfusion study; microspheres; myocardium, blood supply;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Bauer, WR Univ Wurzburg, Inst Med, Josef Schnneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schnneider Str 2 Wurzburg Germany D-97080 y
Citazione:
C. Waller et al., "Myocardial perfusion and intracapillary blood volume in rats at rest and with coronary dilatation: MR imaging in vivo with use of a spin-labeling technique", RADIOLOGY, 215(1), 2000, pp. 189-197

Abstract

PURPOSE: To validate a magnetic resonance (MR) imaging technique that is not first pass and that reveals perfusion and regional blood volume (RBV) inthe intact rat. MATERIALS AND METHODS: Measurement of perfusion was based on the perfusion-sensitive T1 relaxation after magnetic spin labeling of water protons. REVwas determined from steady-state measurements of T1 before and after administration of an intravascular contrast agent. The colored microsphere technique was used as a reference method for perfusion measurement. REV and perfusion maps were obtained with the rats at rest and during administration of3 mg of adenosine phosphate per kilogram of body weight per min ute. RESULTS: At MR imaging, perfusion during resting conditions was 3.5 mL/g/min +/- 0.1 (SEM), and REV was 11.6% +/- 0.6 (SEM). Adenosine phosphate significantly increased perfusion to 4.5 mL/g/min +/- 0.3 (SEM) and decreased mean arterial pressure from 120 mm Hg to 65 mm Hg, which implies a reductionof coronary resistance to 40% of baseline. REV increased consistently to 23.8% +/- 0.6 (SEM). CONCLUSION: The study results show that quantitative mapping of perfusion and REV may be performed noninvasively by means of MR imaging in the intactanimal. The presented method allows determination of vasodilative and perfusion reserve, which reflects the in vivo regulation of coronary microcirculation for a given stimulus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 03:05:42