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Titolo:
Transcatheter arterial chemoembolization for hepatocellular carcinoma in patients with cirrhosis: Evaluation of damage to nontumorous liver tissue-long-term prospective study
Autore:
Caturelli, E; Siena, DA; Fusilli, S; Villani, MR; Schiavone, G; Nardella, M; Balzano, S; Florio, F;
Indirizzi:
Osped Casa Sollievo Sofferenza, IRCCS, Div Gastroenterol, I-71013 San Giovanni Rotondo, Foggia, Italy Osped Casa Sollievo Sofferenza San Giovanni Rotondo Foggia Italy I-71013 Osped Casa Sollievo Sofferenza, IRCCS, Dept Anat & Histopathol, I-71013 San Giovanni Rotondo, Foggia, Italy Osped Casa Sollievo Sofferenza San Giovanni Rotondo Foggia Italy I-71013 Osped Casa Sollievo Sofferenza, IRCCS, Angiog Serv, Dept Diagnost Imaging,I-71013 San Giovanni Rotondo, Foggia, Italy Osped Casa Sollievo SofferenzaSan Giovanni Rotondo Foggia Italy I-71013
Titolo Testata:
RADIOLOGY
fascicolo: 1, volume: 215, anno: 2000,
pagine: 123 - 128
SICI:
0033-8419(200004)215:1<123:TACFHC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERCUTANEOUS ETHANOL INJECTION; OILY CHEMOEMBOLIZATION; HEPATIC RESECTION; TRANSARTERIAL EMBOLIZATION; SYMPTOMATIC TREATMENT; PROGNOSTIC FACTORS; CONTROLLED TRIALS; RANDOMIZED TRIAL; RISK-FACTORS; TRANSPLANTATION;
Keywords:
hepatic arteries, therapeutic embolization; liver, cirrhosis; liver neoplasms; liver neoplasms, chemotherapeutic infusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Caturelli, E Osped Casa Sollievo Sofferenza, IRCCS, Div Gastroenterol, I-71013 San Giovanni Rotondo, Foggia, Italy Osped Casa Sollievo Sofferenza San Giovanni Rotondo Foggia Italy I-71013
Citazione:
E. Caturelli et al., "Transcatheter arterial chemoembolization for hepatocellular carcinoma in patients with cirrhosis: Evaluation of damage to nontumorous liver tissue-long-term prospective study", RADIOLOGY, 215(1), 2000, pp. 123-128

Abstract

PURPOSE: To evaluate damage to cirrhotic liver tissue after transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinoma(HCC). MATERIALS AND METHODS: TACE was performed in 111 patients with HCC that involved less than 30% of the liver. Baseline liver function was evaluated with Child-Pugh scores and other indicators. Eighty-two patients had Child-Pugh class A disease, 27 had class B disease, and two had class C disease. All patients underwent chemotherapy followed by gelatin sponge particle embolization in the proper ("complete" embolization; n = 69) or right or left main ("partial" embolization; n = 42) hepatic artery. Liver function was assessed 4 months later, and 95 patients underwent a second TACE (complete embolization in 57, partial in 38). Liver function was again assessed 4 months later in 60 patients. RESULTS: No patient died. Child-Pugh scores increased in all patients froma mean 5.96 to 6.28 (not significant) and 6.51 (P = .05) after first and second TACEs, respectively. In patients with class A disease, scores increased from a mean 5.37 to 5.73 (P = .01) and 5.89 (P = .001) after first and second TACEs, respectively; in patients with class B disease, scores changedfrom a mean of 7.48 to 7.67 and 7.30 after first and second TACEs, respectively (not significant). CONCLUSION: TACE does not induce significant long-term worsening of liver function in patients with class A or B cirrhosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 17:18:01