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Titolo:
Effects of the competitive nicotinic antagonist erysodine on behavior occasioned or maintained by nicotine: comparison with mecamylamine
Autore:
Mansbach, RS; Chambers, LK; Rovetti, CC;
Indirizzi:
Pfizer Inc, Cent Res, Dept Neurosci, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340 t Res, Dept Neurosci, Groton, CT 06340 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 148, anno: 2000,
pagine: 234 - 242
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIHYDRO-BETA-ERYTHROIDINE; ACETYLCHOLINE-RECEPTORS; ABSTINENCE SYNDROME; RAT-BRAIN; REINSTATEMENT; SUBTYPES; INFUSION; COCAINE; SUBUNIT; BINDING;
Keywords:
nicotine; drug discrimination; self-administration; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Mansbach, RS Pfizer Inc, Cent Res, Dept Neurosci, Eastern Point Rd, Groton, CT 06340 USA Pfizer Inc Eastern Point Rd Groton CT USA 06340 CT 06340 USA
Citazione:
R.S. Mansbach et al., "Effects of the competitive nicotinic antagonist erysodine on behavior occasioned or maintained by nicotine: comparison with mecamylamine", PSYCHOPHAR, 148(3), 2000, pp. 234-242

Abstract

Rationale: The cellular effects of nicotine underlying its addictive liability are thought to be mediated by neuronal nicotinic receptors (nACHRs) inthe central nervous system. It is believed that densely expressed beta 2-containing nACHRs in the central nervous system are responsible for these actions, but few data are available that can directly assess subtype mediation of nicotine's acute subjective and reinforcing effects. Objective: The present study compared the effects of the competitive nACHR antagonist erysodine and the noncompetitive antagonist mecamylamine in rats trained to discriminate or self-administer nicotine, Methods: Adult male rats were trained to disciminate 0.4-mg/kg injections of nicotine from vehicle in a two-leverprocedure of food-maintained behavior, or to self-administer 0.03-mg/kg injections of nicotine under fixed-ratio 5 or progressive-ratio schedules of reinforcement. Additional rats were trained under a food-maintained procedure of lever pressing. Results: Erysodine (0.3-10 mg/kg) and mecamylamine (0.1-1.0 mg/kg) blocked nicotine discrimination, although only erysodine produced the rightward shift that would be predicted of a competitive antagonist. Erysodine (0.32-32 mg/kg) and mecamylamine (0.32-3.2 mg/kg) also selectively reduced nicotine self-administration on a fixed-ratio schedule and lowered break points on a progressive-ratio schedule. Conclusions: Based on the known affinity of erysodine for alpha 4 beta 2 nACHRs and its selectivityrelative to alpha 7 and alpha 1 beta 1 gamma delta receptors, the present data support a critical role of beta 2-containing nACHR constructs in the discriminative and reinforcing actions of nicotine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 11:23:05