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Titolo:
The serotonin-1A receptor antagonist WAY-100635 modifies fluoxetine's antidepressant-like profile on the differential reinforcement of low rates 72-sschedule in rats
Autore:
Cousins, MS; Seiden, LS;
Indirizzi:
Univ Chicago, Dept Pharmacol & Physiol Sci, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 ol & Physiol Sci, Chicago, IL 60637 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 148, anno: 2000,
pagine: 438 - 442
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORCED SWIMMING TEST; REUPTAKE INHIBITORS; 5-HT1A RECEPTORS; FRONTAL-CORTEX; PINDOLOL; COMBINATION; PERFORMANCE; INVOLVEMENT; DEPRESSION; PAROXETINE;
Keywords:
serotonin re-uptake inhibitor; 5-HT-1A receptor; behavior; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Seiden, LS Univ Chicago, Dept Pharmacol & Physiol Sci, 947E 58th St, Chicago, IL 60637 USA Univ Chicago 947E 58th St Chicago IL USA 60637 go, IL 60637 USA
Citazione:
M.S. Cousins e L.S. Seiden, "The serotonin-1A receptor antagonist WAY-100635 modifies fluoxetine's antidepressant-like profile on the differential reinforcement of low rates 72-sschedule in rats", PSYCHOPHAR, 148(4), 2000, pp. 438-442

Abstract

Rationale: Recent preclinical and clinical data suggest that co-administration of a serotonin-1A (5-HT-1A) receptor antagonist with an antidepressantdrug has greater therapeutic efficacy than when the antidepressant drug isadministered alone. Objective: The purpose of the present experiment was to determine whether pretreatment with the selective 5-HT-1A receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(pyridinyl)cyclohexanecarboxamide (WAY-100635; 0.003, 0.03, 0.3 mg/kg, s.c.) would alter the effects of the antidepressant fluoxetine (2.5-10 mg/kg, i.p.) on the differential reinforcement of low-rate 72-s (DRL 72-s) schedule. The DRL 72-s schedule is a behavioral screen selective and sensitive to antidepressant drugs. Results: WAY-100635 had no behavioral effects on its own. The lower doses of fluoxetine (2.5 mg/kg and 5 mg/kg) had no effects, but 10 mg/kg increasedreinforcement rate without affecting response rate, The increase in reinforcement rate was blocked by pretreatment with 0.03 mg/kg and 0.3 mg/kg WAY-100635, although the combination of fluoxetine and WAY-100635 also significantly reduced response rate. Interestingly, 0.003 mg/kg or 0.03 mg/kg WAY-100635 administered with 5.0 mg/kg fluoxetine increased reinforcement rate, even though this dose of fluoxetine had no effect on performance. Conclusion: These data demonstrate that the behavioral effects of fluoxetine are modified by 5-HT-1A receptor blockade.

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Documento generato il 29/09/20 alle ore 07:38:29