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Titolo:
Mechanisms of use-dependent plasticity in the human motor cortex
Autore:
Butefisch, CM; Davis, BC; Wise, SP; Sawaki, L; Kopylev, L; Classen, J; Cohen, LG;
Indirizzi:
NINDS, Human Cort Physiol Sect, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 ort Physiol Sect, NIH, Bethesda, MD 20892 USA NIMH, Lab Syst Neurosci, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA20892 Lab Syst Neurosci, NIH, Bethesda, MD 20892 USA NINDS, Biometry & Field Studies Branch, NIH, Bethesda, MD 20892 USA NINDSBethesda MD USA 20892 d Studies Branch, NIH, Bethesda, MD 20892 USA Univ Rostock, Neurol Klin, D-18055 Rostock, Germany Univ Rostock RostockGermany D-18055 urol Klin, D-18055 Rostock, Germany
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 7, volume: 97, anno: 2000,
pagine: 3661 - 3665
SICI:
0027-8424(20000328)97:7<3661:MOUPIT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; METHYL-D-ASPARTATE; HORIZONTAL CONNECTIONS; MAGNETIC STIMULATION; LAMOTRIGINE; DEXTROMETHORPHAN; EXCITABILITY; BRAIN; PHARMACOKINETICS; ANTICONVULSANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Cohen, LG NINDS, Human Cort Physiol Sect, NIH, Bldg 10,Room 5N234, Bethesda, MD 20892 USA NINDS Bldg 10,Room 5N234 Bethesda MD USA 20892 sda, MD 20892 USA
Citazione:
C.M. Butefisch et al., "Mechanisms of use-dependent plasticity in the human motor cortex", P NAS US, 97(7), 2000, pp. 3661-3665

Abstract

Practicing movements results in improvement in performance and in plasticity of the motor cortex. To identify the underlying mechanisms, we studied use-dependent plasticity in human subjects premedicated with drugs that influence synaptic plasticity. Use-dependent plasticity was reduced substantially by dextromethorphan (an N-methyl-D-aspartate receptor blocker) and by lorazepam [a gamma-aminobutyric acid (GABA) type A receptor-positive allosteric modulator]. These results identify N-methyl-D-aspartate receptor activation and GABAergic inhibition as mechanisms operating in use-dependent plasticity in intact human motor cortex and point to similarities in the mechanisms underlying this form of plasticity and long-term potentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:30:01