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Titolo:
The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus
Autore:
Bi, RF; Broutman, G; Foy, MR; Thompson, RF; Baudry, M;
Indirizzi:
Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Program, Los Angeles, CA 90089 USA Loyola Marymount Univ, Dept Psychol, Los Angeles, CA 90045 USA Loyola Marymount Univ Los Angeles CA USA 90045 Los Angeles, CA 90045 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 7, volume: 97, anno: 2000,
pagine: 3602 - 3607
SICI:
0027-8424(20000328)97:7<3602:TTKAMP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTSYNAPTIC DENSITY FRACTION; ALZHEIMERS-DISEASE; NMDA RECEPTORS; KAINIC ACID; LONG-TERM; NEURONS; CULTURES; TOXICITY; CURRENTS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Baudry, M Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 os Angeles, CA 90089 USA
Citazione:
R.F. Bi et al., "The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus", P NAS US, 97(7), 2000, pp. 3602-3607

Abstract

Estrogen replacement therapy in women is associated with improvement of cognitive deficits and reduced incidence of Alzheimer's disease. The present study indicates that estrogen is neuroprotective against N-methyl-D-aspartate (NMDA)- and kainate-mediated neurotoxicity, an effect mediated by tyrosine kinase/mitogen-activated protein kinase (MAPK) pathways. Estrogen also stimulates tyrosine phosphorylation of NMDA receptors via an src tyrosine kinase/MAPK pathway. Finally, estrogen-mediated enhancement of long-term potentiation in hippocampal slices is mediated by activation of an src tyrosinekinase pathway. Thus, estrogen, by activating an src tyrosine kinase and the extracellular signal-related protein kinase/MAPK signaling pathway, bothenhances NMDA receptor function and long-term potentiation and retains neuroprotective properties against excitotoxicity. These findings warrant further evaluation of the usefulness of estrogenic compounds for the treatment of Alzheimer's disease and other neurodegenerative diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:08:59