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Titolo:
Transplatin-modified oligonucleotides as modulators of gene expression
Autore:
Giraud-Panis, MJ; Leng, M;
Indirizzi:
CNRS, Ctr Biophys Mol, F-45071 Orleans 2, France CNRS Orleans France 2CNRS, Ctr Biophys Mol, F-45071 Orleans 2, France
Titolo Testata:
PHARMACOLOGY & THERAPEUTICS
fascicolo: 3, volume: 85, anno: 2000,
pagine: 175 - 181
SICI:
0163-7258(200003)85:3<175:TOAMOG>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRASTRAND CROSS-LINKS; ANTISENSE OLIGONUCLEOTIDES; STRANDED OLIGONUCLEOTIDES; MONOFUNCTIONAL ADDUCTS; ISOMERIZATION REACTION; DNA; TRANS-DIAMMINEDICHLOROPLATINUM(II); TELOMERASE; BINDING; CELLS;
Keywords:
transplatin; interstrand cross-links; oligonucleotides; antisense strategy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Leng, M CNRS, Ctr Biophys Mol, Rue Charles Sadron, F-45071 Orleans 2, France CNRS Rue Charles Sadron Orleans France 2 -45071 Orleans 2, France
Citazione:
M.J. Giraud-Panis e M. Leng, "Transplatin-modified oligonucleotides as modulators of gene expression", PHARM THERA, 85(3), 2000, pp. 175-181

Abstract

Transplatin [trans-diamminedichloroplatinum(II)], contrary to its stereoisomer cisplatin, is clinically inactive. However, like cisplatin, it binds to DNA. In the first part of this review, some results on the interactions between transplatin and double-stranded DNA are presented. The major bifunctional adducts are interstrand cross-links. Intrastrand cross-links are not formed. On the other hand, intrastrand cross-links are formed in the reaction between single-stranded DNA and transplatin. Some properties of the intrastrand cross-links at GNG sites (N is a nucleotide) are described. The (G1,G3)-intrastrand cross-links rearrange into interstrand cross-links as soonas the platinated oligonucleotides are paired with their complementary strands. The linkage isomerization reaction is exclusively triggered by the formation of a double helix. The potential use of these platinated oligonucleotides to block the cellular machinery specifically and irreversibly is discussed. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 17:04:31