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Titolo:
Cationic amino acid transport through system y+L in erythrocytes of patients with lysinuric protein intolerance
Autore:
Boyd, CAR; Deves, R; Laynes, R; Kudo, Y; Sebastio, G;
Indirizzi:
Univ Oxford, Dept Human Anat & Genet, Oxford OX1 3QX, England Univ OxfordOxford England OX1 3QX Anat & Genet, Oxford OX1 3QX, England Univ Chile, Fac Med, Inst Ciencias Biomed, Santiago 7, Chile Univ Chile Santiago Chile 7 Med, Inst Ciencias Biomed, Santiago 7, Chile Univ Naples Federico II, Dipartimento Pediat, I-80131 Naples, Italy Univ Naples Federico II Naples Italy I-80131 diat, I-80131 Naples, Italy
Titolo Testata:
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
fascicolo: 5, volume: 439, anno: 2000,
pagine: 513 - 516
SICI:
0031-6768(200003)439:5<513:CAATTS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE; IDENTIFICATION;
Keywords:
amino acid transport; CD98hc; LPI; lysinuric protein intolerance; system y plus L;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Boyd, CAR Univ Oxford, Dept Human Anat & Genet, Oxford OX1 3QX, England Univ Oxford Oxford England OX1 3QX et, Oxford OX1 3QX, England
Citazione:
C.A.R. Boyd et al., "Cationic amino acid transport through system y+L in erythrocytes of patients with lysinuric protein intolerance", PFLUG ARCH, 439(5), 2000, pp. 513-516

Abstract

We test the hypothesis that lysinuric protein intolerance (LPI), a rare autosomal recessive defect of cationic amino acid transport, results from theabsence of the recently described y(+)L amino acid transporter. We comparefluxes of lysine (1 mu M) into erythrocytes of normal subjects with those of patients homozygous for the LPI mutation. No significant differences influxes through system y(+)L in normal or LPI cells were found, excluding thepossibility that system y(+)L cannot be expressed in patients with LPI. Reasons for supposing that there may be tissue-specific processing of two recently described genes encoding the y(+)L transporter are discussed. Polymerase chain reaction measurement of expression of these two genes in an erythroleukemic cell line suggests that alternatively there may be an as-yet-unidentified additional member of this gene family.

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Documento generato il 28/01/21 alle ore 07:51:33