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Titolo:
Salivary cotinine levels in children presenting with wheezing to an emergency department
Autore:
Chang, MY; Hogan, AD; Rakes, GP; Ingram, JM; Hoover, GE; Platts-Mills, TAE; Heymann, PW;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Dept Pediat, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Med Coll Virginia, Dept Internal Med, Charlottesville, VA USA Med Coll Virginia Charlottesville VA USA al Med, Charlottesville, VA USA Univ Virginia, Hlth Sci Ctr, Dept Internal Med, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 4, volume: 29, anno: 2000,
pagine: 257 - 263
SICI:
8755-6863(200004)29:4<257:SCLICP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENVIRONMENTAL TOBACCO-SMOKE; BRONCHIAL RESPONSIVENESS; CIGARETTE-SMOKING; MATERNAL SMOKING; PARENTAL SMOKING; LUNG-FUNCTION; 1ST YEAR; EXPOSURE; ASTHMA; NICOTINE;
Keywords:
wheezing; asthma; bronchiolitis; environmental tobacco smoke; cotinine; children; infants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Heymann, PW Univ Virginia, Hlth Sci Ctr, Dept Pediat, Bldg MR-4,Room 5061,Charlottesville, VA 22908 USA Univ Virginia Bldg MR-4,Room 5061 Charlottesville VA USA 22908
Citazione:
M.Y. Chang et al., "Salivary cotinine levels in children presenting with wheezing to an emergency department", PEDIAT PULM, 29(4), 2000, pp. 257-263

Abstract

We set out to evaluate salivary cotinine concentrations to judge tobacco smoke exposure among infants and children, and to examine the results in relation to age and wheezing. This was a case-control study of wheezing children (n = 165) and children without respiratory tract symptoms (n = 106) who were enrolled in the Pediatric Emergency Department at the University of Virginia. The age range of both wheezing and control patients was 2 months to16 years. Questionnaires were combined with cotinine assays in saliva to evaluate exposure to environmental tobacco smoke (ETS) for each child. The prevalence of exposure to one or more smokers at home was high (68%); and 43% of the children enrolled were exposed to ETS from their mothers. According to the questionnaires, and after adjusting for age and race, a wheezing child in this study was more likely than a control to be exposed to atleast one smoker at home (odds ratio = 1.9; 95% CI = 1.1-3.4). However, the odds of exposure to ETS from smoking mothers did not differ significantlybetween wheezing and control patients, and no significant association was found between the presence of wheezing and salivary cotinine levels. Among children exposed to ETS at home, cotinine levels were significantly higher in saliva from those under the age of two years, and from toddlers aged 2 and 3 years, compared to values from children over age 4 years. Moreover, the number of smokers in the home strongly influenced cotinine levels from children under age 4 years. In addition, higher cotinine levels were observedin saliva from children under age 2 years who were exposed to ETS from their mothers. Cotinine levels were similar and significantly correlated in paired samples of saliva and serum from children under 4 years of age (n = 54), (r = 0.92, P < 0.001). Based on information gathered from questionnaires, the results indicate that wheezing children were more likely than controls to be exposed to ETS athome. However, significant differences in ETS exposure between wheezing and control groups with respect to maternal smoke exposure or comparisons of salivary cotinine levels were not apparent. It was clear that determinations of salivary cotinine for monitoring the prevalence and intensity of household smoke exposure in this study were most valuable during the first 4 years of life. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 31/03/20 alle ore 15:10:44