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Titolo:
Hippocampal lesions enhance startle gating-disruptive effects of apomorphine in rats: A parametric assessment
Autore:
Swerdlow, NR; Taaid, N; Halim, N; Randolph, E; Kim, YK; Auerbach, P;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 96, anno: 2000,
pagine: 523 - 536
SICI:
0306-4522(2000)96:3<523:HLESGE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-GLUTAMATE INTERACTIONS; MEDIAL PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; PREPULSE INHIBITION; ACOUSTIC STARTLE; ANIMAL-MODEL; SCHIZOPHRENIC-PATIENTS; VENTRAL HIPPOCAMPUS; SENSORIMOTOR; ABNORMALITIES;
Keywords:
dopamine; hippocampus; nucleus accumbens; prepulse inhibition; schizophrenia; startle reflex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Swerdlow, NR Univ Calif San Diego, Sch Med, Dept Psychiat, 9500 Gillman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gillman Dr La Jolla CA USA 92093 SA
Citazione:
N.R. Swerdlow et al., "Hippocampal lesions enhance startle gating-disruptive effects of apomorphine in rats: A parametric assessment", NEUROSCIENC, 96(3), 2000, pp. 523-536

Abstract

Prepulse inhibition of the startle reflex is an operational measure of sensorimotor gating that is impaired in schizophrenia patients and dopamine agonist-treated rats. Previous reports demonstrated an enhanced sensitivity to the prepulse inhibition-disruptive effects of the D-1/D-2 agonist apomorphine in adult rats four weeks after cytotoxic lesions of the hippocampus, but left unanswered several important questions regarding the nature of thisapparent lesion-induced dopamine supersensitivity. Because of the potential importance of this model to current theories of the pathophysiology of schizophrenia, studies now assessed specific features of this effect of hippocampus lesions on prepulse inhibition in rats. The enhanced prepulse inhibition-disruptive effects of apomorphine in ventral hippocampus-lesioned ratswere unaffected by startle pulse intensity, suggesting an independence of this lesion effect from potential ceiling effects of elevated startle magnitude. These lesion effects were observed four weeks post-lesion, but not two weeks post-lesion, suggesting a delayed development of this phenomenon. No enhancement of apomorphine sensitivity was observed in rats four weeks after lesions restricted to the dorsal hippocampus; in contrast, these lesions significantly increased "no-drug" levels of prepulse inhibition. Ventral hippocampus-lesioned rats exhibited a significant reduction in prepulse inhibition after subthreshold doses of either the selective D-2-family agonistquinpirole or the partial D-1 agonist SKF 38393, suggesting that activation of either receptor family is adequate for the expression of this effect of ventral hippocampus lesions. This may be an important paradigm for understanding the contribution of ventral hippocampus dysfunction to the neurobiology of impaired sensorimotor gating in neuropsychiatric populations. (C) 2000 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 07:22:12