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Titolo:
Enhanced nucleus accumbens dopamine and plasma corticosterone stress responses in adult rats with neonatal excitotoxic lesions to the medial prefrontal cortex
Autore:
Brake, WG; Flores, G; Francis, D; Meaney, MJ; Srivastava, LK; Gratton, A;
Indirizzi:
McGill Univ, Douglas Hosp Res Ctr, Dept Psychiat, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Ctr, Dept Psychiat, Montreal, PQ, Canada Univ Autonoma Puebla, Inst Fisiol, Puebla 72570, Mexico Univ Autonoma Puebla Puebla Mexico 72570 st Fisiol, Puebla 72570, Mexico
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 96, anno: 2000,
pagine: 687 - 695
SICI:
0306-4522(2000)96:4<687:ENADAP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; CARBON-FIBER MICROELECTRODES; SPATIAL DELAYED ALTERNATION; FREELY-BEHAVING RATS; FRONTAL-CORTEX; LOCOMOTOR RESPONSE; CORTICAL DOPAMINE; ANIMAL-MODEL; TOPOGRAPHICAL ORGANIZATION; 6-HYDROXYDOPAMINE LESIONS;
Keywords:
voltammetry; glucocorticoids; HPA axis; ibotenic acid; prepulse inhibition; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
85
Recensione:
Indirizzi per estratti:
Indirizzo: Gratton, A McGill Univ, Douglas Hosp Res Ctr, Dept Psychiat, 6875 LaSalle Blvd, Montreal, PQ, Canada McGill Univ 6875 LaSalle Blvd Montreal PQ Canada l, PQ, Canada
Citazione:
W.G. Brake et al., "Enhanced nucleus accumbens dopamine and plasma corticosterone stress responses in adult rats with neonatal excitotoxic lesions to the medial prefrontal cortex", NEUROSCIENC, 96(4), 2000, pp. 687-695

Abstract

The medial prefrontal cortex modulates the nucleus accumbens dopamine response to stress and has been implicated in feedback regulation of hypothalamic-pituitary-adrenal axis activation by stress. Here we report on the effects of bilateral neonatal (postnatal day 7) ibotenate-induced lesions to themedial prefrontal cortex on nucleus accumbens dopamine and neuroendocrine function in adult rats. Voltammetry was used to monitor the dopamine response to each of five, once-daily exposures to tail-pinch stress whereas alterations in neuroendocrine function were determined from the plasma corticosterone response to a single 20-min episode of restraint stress. Potential lesion-induced deficits in sensory-motor gating were assessed by measuring prepulse inhibition of the acoustic startle response before and after repeated stress. Our data show that each daily stress episode elicited larger and longer-lasting dopamine increases in prefrontal cortex-lesioned animals than in sham-lesioned controls. Furthermore, greater stress-induced elevationsin plasma corticosterone were seen in lesioned animals than in their sham-lesioned counterparts. However, while repeated stress potentiated startle responses in animals of both groups, there was no effect of lesion on the amplitude or on prepulse inhibition of the startle response. Together, these findings indicate that neonatal prefrontal cortex damage can lead to changes in mesolimbic dopamine and neuroendocrine function during adulthood. They also add to a growing body of experimental and clinical evidence implicating abnormal prefrontal cortex neuronal development in the pathophysiology of schizophrenia and other disorders linked to central dopamine dysfunction. (C) 2000 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 18/09/20 alle ore 16:05:23