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Titolo:
Systemic and intra-accumbens administration of amphetamine differentially affects cortical acetylcholine release
Autore:
Arnold, HM; Nelson, CL; Neigh, GN; Sarter, M; Bruno, JP;
Indirizzi:
Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 ept Psychol, Columbus, OH 43210 USA Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 pt Neurosci, Columbus, OH 43210 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 96, anno: 2000,
pagine: 675 - 685
SICI:
0306-4522(2000)96:4<675:SAIAOA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTOR LIGANDS; EXTRACELLULAR DOPAMINE LEVELS; NUCLEUS-ACCUMBENS; VENTRAL PALLIDUM; BIDIRECTIONAL MODULATION; CHOLINERGIC SYSTEMS; COGNITIVE FUNCTIONS; PREFRONTAL CORTEX; RATS; NEURONS;
Keywords:
acetylcholine; dopamine; amphetamine; basal forebrain; prefrontal cortex; nucleus accumbens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Bruno, JP Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA Ohio StateUniv Columbus OH USA 43210 l, Columbus, OH 43210 USA
Citazione:
H.M. Arnold et al., "Systemic and intra-accumbens administration of amphetamine differentially affects cortical acetylcholine release", NEUROSCIENC, 96(4), 2000, pp. 675-685

Abstract

The present experiments tested the hypothesis that the amphetamine-inducedincrease in dopamine release in the nucleus accumbens represents a necessary and sufficient component of the ability of systemically administered amphetamine to stimulate cortical acetylcholine release. The effects of systemic or intra-accumbens administration of amphetamine on accumbens dopamine release and cortical acetylcholine release were assessed simultaneously in awake animals equipped with dialysis probes inserted into the shell of the nucleus accumbens and the medial prefrontal cortex. Additionally, the ability of intra-accumbens administration of dopamine D-1 and D-2 receptor antagonists to attenuate the effects of systemic amphetamine on cortical acetylcholine was tested. The effects of all treatments were assessed in interaction with a stimulus-induced activation of cortical acetylcholine release to account for the possibility that the demonstration of the trans-synaptic effects of accumbens dopamine requires pre-activation of basal forebrain circuits. Systemic amphetamine resulted in increases in basal cortical acetylcholine and accumbens dopamine efflux. Intra-accumbens administration of amphetamine substantially increased accumbens dopamine efflux, but did not significantly affect cortical acetylcholine efflux. Furthermore, intra-accumbensadministration of sulpiride or SCH 23390 did not attenuate the systemic amphetamine-induced increase in cortical acetylcholine efflux. Collectively, the present data suggest that increases in accumbens dopamine release are neither sufficient nor necessary for the effects of systemically administered amphetamine on cortical acetylcholine release. The systemic amphetamine-induced increase in cortical acetylcholine may be mediated via multiple, parallel pathways and may not be attributable to a single afferent pathway of the basal forebrain. (C) 2000 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 19/01/20 alle ore 08:55:43