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Titolo:
IDENTIFICATION OF A CHEMOKINE RECEPTOR ENCODED BY HUMAN CYTOMEGALOVIRUS AS A COFACTOR FOR HIV-1 ENTRY
Autore:
PLESKOFF O; TREBOUTE C; BRELOT A; HEVEKER N; SEMAN M; ALIZON M;
Indirizzi:
INST COCHIN GENET MOL,INSERM,U332,22 RUE MECHAIN F-75014 PARIS FRANCE INST COCHIN GENET MOL,INSERM,U332 F-75014 PARIS FRANCE UNIV PARIS 07,LAB IMMUNODIFFERENCIAT F-75005 PARIS FRANCE
Titolo Testata:
Science
fascicolo: 5320, volume: 276, anno: 1997,
pagine: 1874 - 1878
SICI:
0036-8075(1997)276:5320<1874:IOACRE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; BRAIN-DERIVED CELLS; CMV INFECTION; ENVELOPE GLYCOPROTEIN; T-CELLS; TYPE-1; AIDS; REPLICATION; HEMOPHILIACS; LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
O. Pleskoff et al., "IDENTIFICATION OF A CHEMOKINE RECEPTOR ENCODED BY HUMAN CYTOMEGALOVIRUS AS A COFACTOR FOR HIV-1 ENTRY", Science, 276(5320), 1997, pp. 1874-1878

Abstract

The human cytomegalovirus encodes a beta-chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human cell lines by primary isolates of HIV-1 and HIV-2, as well as fusion of these cell lines with cells expressing the viral envelope proteins. In addition, US28 mediated infection by cell line-adapted HIV-1 for which CXCR4 was an entry cofactor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:25:37