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Titolo:
Co-localization of PKC epsilon with various GABA(A) receptor subunits in the mouse limbic system
Autore:
Olive, MF; Hodge, CW;
Indirizzi:
Univ Calif San Francisco, Dept Neurol, Ernest Gallo Clin & Res Ctr, Emeryville, CA 94608 USA Univ Calif San Francisco Emeryville CA USA 94608 Emeryville, CA 94608 USA
Titolo Testata:
NEUROREPORT
fascicolo: 4, volume: 11, anno: 2000,
pagine: 683 - 687
SICI:
0959-4965(20000320)11:4<683:COPEWV>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; A RECEPTOR; PHOSPHORYLATION SITES; INTRACELLULAR DOMAINS; ANTIBODIES; BRAIN; ACTIVATION; CURRENTS;
Keywords:
basolateral amygdala; cingulate cortex; dentate gyrus; epsilon; GABA; limbic system; nucleus accumbens; prelimbic cortex; protein kinase C; receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Olive, MF Univ Calif San Francisco, Dept Neurol, Ernest Gallo Clin & Res Ctr, 5858 Horton St,Suite 200, Emeryville, CA 94608 USA Univ Calif San Francisco 5858 Horton St,Suite 200 Emeryville CA USA 94608
Citazione:
M.F. Olive e C.W. Hodge, "Co-localization of PKC epsilon with various GABA(A) receptor subunits in the mouse limbic system", NEUROREPORT, 11(4), 2000, pp. 683-687

Abstract

The distribution of PKC epsilon and its co-localization with various GABA(A) receptor subunits within limbic structures of the mouse brain was examined by fluorescence immunohistochemistry. Levels of PKC epsilon immunoreactivity were highest in the cingulate cortex and dentate gyrus, moderate in the nucleus accumbens, and lowest in the prelimbic cortex and basolateral amygdala. Co-localization of PKC epsilon immunoreactivity with the GABA(A) receptor alpha(1), beta(2/3), and gamma(2) subunits varied by subunit and brain region examined, with the majority of co-localization occuring in the dentate gyrus, nucleus accumbens and basolateral amygdala. These results demonstrate that PKC epsilon may interact with GABA(A) receptors in a subunit- and region-specific manner, and provide a potential anatomical basis for recent behavioral and biochemical evidence that PKC epsilon modulates GABA(A) receptor function. NeuroReport 11:683-687 (C) 2000 Lippincott Williams & Wilkins.

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Documento generato il 05/04/20 alle ore 03:30:49