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Titolo:
Decreased GDNF mRNA expression in dorsal spinal cord of unilateral arthritic rat
Autore:
Fang, M; Wang, Y; Liu, HX; Liu, XS; Han, JS;
Indirizzi:
Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China Beijing Med Univ Beijing Peoples R China 100083 100083, Peoples R China
Titolo Testata:
NEUROREPORT
fascicolo: 4, volume: 11, anno: 2000,
pagine: 737 - 741
SICI:
0959-4965(20000320)11:4<737:DGMEID>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIN;
Keywords:
arthritis; chronic pain; GDNF; neurotrophin; rat; spinal cord;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Han, JS Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China Beijing Med Univ Beijing Peoples R China 100083 Peoples R China
Citazione:
M. Fang et al., "Decreased GDNF mRNA expression in dorsal spinal cord of unilateral arthritic rat", NEUROREPORT, 11(4), 2000, pp. 737-741

Abstract

It is now well established that nerve growth factor (NGF) plays a key rolein inflammation-induced hyperalgesia. It was also reported that brain derived neurotrophic factor (BDNF), another member of neurotrophins, contributed to the pain pathway as a neurotransmitter in the CNS. The present work demonstrated a down-regulation of glial cell line-derived neurotrophic factor(GDNF) mRNA expression in dorsal spinal cord in complete Freund's adjuvant-induced unilateral arthritic rats serving as a chronic pain model. The fast occurring and long lasting down-regulations suggest that GDNF might contribute to pain pathway in a way different from neurotrophins and might play a role in the maintenance of chronic pain status. NeuroReport 11:737-741 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:18:59