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Titolo:
An animal model of neuropathic pain employing injury to the sciatic nerve branches
Autore:
Lee, BH; Won, R; Baik, EJ; Lee, SH; Moon, CH;
Indirizzi:
Yonsei Univ, Coll Med, Med Res Ctr, Seoul 120752, South Korea Yonsei UnivSeoul South Korea 120752 Res Ctr, Seoul 120752, South Korea Yonsei Univ, Coll Med, Inst Brain Res, Seoul 120752, South Korea Yonsei Univ Seoul South Korea 120752 rain Res, Seoul 120752, South Korea Ajou Univ, Sch Med, Dept Physiol, Suwon 442749, South Korea Ajou Univ Suwon South Korea 442749 pt Physiol, Suwon 442749, South Korea
Titolo Testata:
NEUROREPORT
fascicolo: 4, volume: 11, anno: 2000,
pagine: 657 - 661
SICI:
0959-4965(20000320)11:4<657:AAMONP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL-ROOT GANGLIA; PERIPHERAL NEUROPATHY; INDEPENDENT PAIN; NEONATAL RATS; SYMPATHECTOMY; ADULT; CRYONEUROLYSIS; GUANETHIDINE; DISORDERS; HINDPAW;
Keywords:
animal model; behavior; neuropathic pain; sciatic nerve; sympathetic nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, BH Yonsei Univ, Coll Med, Med Res Ctr, CPO Box 8044, Seoul 120752, South Korea Yonsei Univ CPO Box 8044 Seoul South Korea 120752 52, South Korea
Citazione:
B.H. Lee et al., "An animal model of neuropathic pain employing injury to the sciatic nerve branches", NEUROREPORT, 11(4), 2000, pp. 657-661

Abstract

The present study was conducted to develop a new animal model of neuropathic pain employing injury to the distal sciatic nerve branches. Under halothane anesthesia, the tibial, sural, and/or common peroneal nerves were injured and neuropathic pain behaviors were compared among different groups of rats. Different types of injury produced different levels of neuropathic pain. Rats with injury to the tibial and sural nerves showed the most vigorousmechanical allodynia, cold allodynia, and spontaneous pain. These neuropathic pain behaviors were not relieved by functional sympathectomy using guanethidine. The results suggested that injury to the tibial and sural nerves,while leaving the common peroneal nerve intact, can be used as a new animal model of neuropathic pain and that this model represents sympathetically independent pain (SIP). The present animal model is very simple to produce injury and can produce profound and reliable pain behaviors. These featuresenable the new animal model to be a useful tool in elucidating the mechanisms of neuropathic pain, especially SIP. NeuroReport 11:657-661 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:41:35