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Titolo:
The disruptive effect of cocaine on prepulse inhibition is prevented by repeated administration in rats
Autore:
Byrnes, JJ; Hammer, RP;
Indirizzi:
Tufts Univ, New England Med Ctr, Dept Psychiat, Sch Med, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 pt Psychiat, Sch Med, Boston, MA 02111 USA Tufts Univ, New England Med Ctr, Dept Pharmacol & Expt Therapeut, Sch Med,Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 pt Therapeut, Sch Med,Boston, MA 02111 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 22, anno: 2000,
pagine: 551 - 554
SICI:
0893-133X(200005)22:5<551:TDEOCO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE AGONISTS; NUCLEUS-ACCUMBENS; STARTLE REFLEX; SENSITIZATION; AMPHETAMINE; TRANSMISSION; APOMORPHINE; PSYCHOSIS; STRESS;
Keywords:
behavioral sensitization; cocaine; prepulse inhibition; schizophrenia; sensorimotor gating;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Hammer, RP Tufts Univ, New England Med Ctr, Dept Psychiat, Sch Med, Box 1007,750 Washington St, Boston, MA 02111 USA Tufts Univ Box 1007,750 Washington St Boston MA USA 02111 1 USA
Citazione:
J.J. Byrnes e R.P. Hammer, "The disruptive effect of cocaine on prepulse inhibition is prevented by repeated administration in rats", NEUROPSYCH, 22(5), 2000, pp. 551-554

Abstract

These experiments tested the hypothesis that pretreatment with a behaviorally sensitizing regimen of cocaine alters the ability of cocaine to disruptprepulse inhibition (PPI). Male Sprague-Dawley rats were treated with cocaine (30 mg/kg, i.p.) or saline vehicle for seven consecutive days followed by challenge treatment seven days later. Repeated cocaine treatment produced sensitization of stereotyped activity. Cocaine challenge following repeated vehicle treatment significantly reduced PPI, but this effect was completely abolished by repeated cocaine treatment. These data suggest that neuroadaptation following repeated treatment might prevent PPI disruption caused by psychomotor stimulants. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 05:15:15