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Titolo:
Effects of acute metabolic stress on striatal dopamine release in healthy volunteers
Autore:
Adler, CM; Elman, I; Weisenfeld, N; Kestler, L; Pickar, D; Breier, A;
Indirizzi:
NIMH, Expt Therapeut Branch, NIH, Bethesda, MD 20892 USA NIMH Bethesda MDUSA 20892 Therapeut Branch, NIH, Bethesda, MD 20892 USA Lilly Res Labs, Indianapolis, IN USA Lilly Res Labs Indianapolis IN USALilly Res Labs, Indianapolis, IN USA Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46204 USA Indiana Univ Indianapolis IN USA 46204 ychiat, Indianapolis, IN 46204 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 22, anno: 2000,
pagine: 545 - 550
SICI:
0893-133X(200005)22:5<545:EOAMSO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; PLASMA HOMOVANILLIC-ACID; C-11 RACLOPRIDE BINDING; EXCITATORY AMINO-ACIDS; PREFRONTAL CORTEX; AXIS ACTIVATION; MENTAL STRESS; LIFE EVENTS; SCHIZOPHRENIA; HYPOGLYCEMIA;
Keywords:
2-deoxyglucose; glucoprivation; striatum; dopamine; raclopride; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Adler, CM Univ Cincinnati, Coll Med, Dept Psychiat, 231 Bethesda Ave, Cincinnati, OH45267 USA Univ Cincinnati 231 Bethesda Ave Cincinnati OH USA 45267 267 USA
Citazione:
C.M. Adler et al., "Effects of acute metabolic stress on striatal dopamine release in healthy volunteers", NEUROPSYCH, 22(5), 2000, pp. 545-550

Abstract

Several lines of evidence indicate that a variety of metabolic stressors, including acute glucose deprivation are associated with dopamine release. Pharmacologic doses of the glucose analogue, 2-deoxyglucose (2DG) cause acute glucoprivation and are associated with enhanced dopamine turnover in preclinical studies. In this study, we utilized [C-11]raclopride PET to examine2DG-induced striatal dopamine release in healthy volunteers. Six healthy volunteers underwent PET scans involving assessment of 2DG-induced (40 mg/kg) decrements in striatal binding of the D-2/D-3 receptor radioligand [C-11]raclopride. Decreases in [C-11]raclopride specific binding reflect 2DG-induced changes in synaptic dopamine. Specific binding significantly decreased following 2DG administration, reflecting enhanced synaptic dopamine concentrations (p = .02). The administration of 2DG is associated with significantstriatal dopamine release in healthy volunteers. Implications of these data for investigations of the role of stress in psychiatric disorders are discussed. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 17:26:33